摘要
当组织损伤发生后,骨髓间充质干细胞逆趋化因子浓度梯度迁移至病变处,通过分化为受损细胞、分泌多种细胞因子如肝细胞生长因子等,及其免疫调节等机制,发挥组织修复作用;肝细胞生长因子是间充质干细胞的重要趋化因子,它可抑制间充质干细胞的增殖、并诱导其向肝细胞及上皮细胞系分化。骨髓间充质干细胞参与受损组织的修复过程是复杂的,其作用机制主要表现在归巢至受损部位,局部微环境下的正确定向分化和抑制宿主的免疫等方面。随着研究的进一步深入,骨髓间充质干细胞参与受损组织修复作用机制将会逐步被明确,移植有治疗效果的行基因修饰的骨髓间充质干细胞,及采取其他可增强细胞移植的治疗效果,增强干细胞的修复作用,有望更好的用于指导临床治疗工作。
After the tissue injuries appear, bone marrow mesenchymal stem cells （MSCs） migrate to the lesion place against the chemokine concentration gradient and produce natural compensatory repair by differentiation of the injured cells, immunological regulation and paracrine of various cytokines, such as hepatocyte growth factor （HGF）. HGF is one of the important chemokine factors of MSCs. It can inhibit proliferation of MSCs and induce MSCs into hepatocytes and epithelial cells. However, the mechanisms of MSCs on the injured tissue repairing are complicated, and the underlying mechanism consists of homing to the injured lesion, correct oriented differentiation of local microenvironment and in inhibition on the host immunity. With the deeper research, the mechanism of reparative process MSCs acting on damaged tissue will be elucidated gradually. It may be helpful for the instruction of the clinical treatment to engraft MSCs which are modified with effective genes and to enhance the ability of cell engraftment.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2009年第46期9143-9146,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
国家自然科学基金面上项目(30871120)~~
