摘要
目的探讨人骨肉瘤组织中endocan、血管内皮生长因子(VEGF)的表达状况及其与临床病理资料之间的相关性。方法应用SP法对34例经手术切除和病理证实的骨肉瘤组织中endocan、VEGF蛋白的表达进行检测。结果Endocan在骨瘤组织胞质中呈阳性表达,肿瘤周围的血管内皮细胞呈阳性表达。对照组表达无明显表达。分别记录各组的平均光密度(MOD),采用独立样本的t检验分析,两组之间差异有统计学意义。比较endocan、VEGF的MOD值,经Pearson相关统计分析,两组之间差异有统计学意义。En-docan、VEGF的MOD值与患者年龄及性别无相关性,与患者病程及肺转移有明显相关性;endocan、VEGF的MOD与肿瘤的类型有相关性。结论Endocan在骨肉瘤组织中有明显的表达,其表达与骨肉瘤的生长、转移有关,提示检测en-docan的表达对骨肉瘤的预后判断可能有一定的指导意义。
Objective To evaluate the expression of endocan and VEGF （vascular endothelial cell growth factor, VEGF） in osteosarcoma tissues and studied the clinicopathological characteristics and its clinical significance. Methods The expression of endoean and VEGF in 34 cases of oseosarcoma were examined with SP immunohisto- chemical technique. Results Endocan was high expressed in the cytoplasm of osteosareoma organization, and the vascular endothelial cells around the tumor were positived. There was no obvious in control group. Each of the mean value of optical density （MOD） was recorded. The differences between them were statistically significant after using independent sample t-test. The difference of endocan and VEGF＇s MOD was statistically significant after Pearson related statistical analysis. Through the analysis of its clinical data, we found： there were no statistical significance in age and sex; there had obvious difference in course and lung metastases, that was statistically significant; there had difference in types of tumors. Conclusion Endocan is expressed in osteosarcoma. There is correlation between the expression of endocan and the growth, transfer of oeteosarcoma.
出处
《安徽医科大学学报》
CAS
北大核心
2009年第6期695-698,共4页
Acta Universitatis Medicinalis Anhui
关键词
骨肉瘤
血管内皮生长因子
osteosarcoma
vascular endothelial growth factors
