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兔腹主动脉易损斑块模型的建立及其血管内超声特征 被引量：6

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摘要 目的建立兔腹主动脉易损斑块(VP)模型并探讨其血管内超声(IVUS)影像学特征。方法20只雄性新西兰大白兔经球囊扩张损伤腹主动脉,高脂喂养8周后行IVUS检查和病理组织学检查。结果15只兔子成功建立VP模型,病理切片发现斑块54层,其中37层(68.5%)为VP。经IVUS检查,VP处斑块面积、管腔狭窄率、偏心指数均明显高于纤维性斑块(P<0.05)。VP正性重构的比例显著高于纤维性斑块(71.8%vs 16.7%,P<0.01)。与病理组织学比较,IVUS识别VP的敏感性和特异性分别为86.5%和88.7%。结论球囊扩张+高脂饮食方法可成功建立兔腹主动脉VP模型,IVUS对识别VP有较好的价值,VP的IVUS特征为偏心狭窄和正性重构。
作者 方红城 苏又苏 吴京兰 陈路 方叶青 谢培益 陈菲 高得宏 李明华
机构地区 广东医学院附属深圳市第六人民医院心内科 广东医学院附属深圳市第六人民医院放射科 广东医学院附属深圳市第六人民医院病理科
出处 《广东医学》 CAS CSCD 北大核心 2009年第12期1781-1783,共3页 Guangdong Medical Journal
基金 广东省深圳市科技局项目(编号:200803177) 广东省深圳市南山区科技局项目(编号:科2006174-6)
关键词 易损斑块 血管内超声 动物模型 兔
分类号 R589.2 [医药卫生—内分泌] R543.3 [医药卫生—心血管疾病]
  • 相关文献

参考文献14

  • 1FUSTER V, BADIMON L, BADIMON J J, et al. The pathogenesis of coronary artery disease and the acute coronary syndromes [J]. N Engl J Med, 1992, 326:242 -250.
  • 2SHAH P K. Plaque disruption and coronary thrombosis:new insight into pathogenesis and prevention[ J]. Clin Cardio, 1997, 20 (Ⅱ) : 38 -44.
  • 3仲琳,张运,张梅,季哓平,陈文强,姚桂华,丁士芳,张鹏飞.兔动脉粥样硬化易损斑块模型的建立[J].基础医学与临床,2005,25(4):370-374. 被引量：30
  • 4VIRMANI R, BURKE A P, KOLODGIE F D, et al. Pathology of the thin - cap fibroatheroma: a type of vulnerable plaque [ J ]. J Interv Cardiol, 2003, 16 (3) : 267 - 272.
  • 5MINTZ G S, NISSEN S E, ANDERSON W D, et al. American College of Cardiology Clinical Expert Consensus Document Standards for Acquistion, Measure and Reporting of Intravascular Ultrasound Studies (IVUS). A report of the American College of Cardiology Task Force on Clinicial Expert Consensus Documents [ J ]. J Am Coil Cardiol, 2001, 37 : 1478 - 1492.
  • 6NAGHAVI M, LIBBY P, FALK E, et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I [ J ]. Circulation, 2003, 108 : 1664 - 1672.
  • 7BURKE A P, FARB A, MALCOM G T, et al. Coronary risk factors and plaque morphology in men with coronary disease who died suddenly[J]. N Engl J Med, 1997, 336:1276-1282.
  • 8CONSTANTINIDES P, CHAKRAVARTI R N. Rabbit arterial thrombosis production by systemic procedures [J]. Arch Pathol, 1961, 72(8) : 197 -208.
  • 9REKHTER M D, HICKS G W, BRAMMER D W, et al. Animal model that mimics atherosclerotic plaque rupture [ J l, Cir Res, 1998, 82(7) :705 -713.
  • 10JOHNSON J L, JACKSON C L. Atherosclerotic plaque rupture in the apoliproteinE knockout mouse [ J ]. Atherosclerosis, 2000, 154 (2) : 399 - 406.

二级参考文献12

  • 1Libby P. Changing concepts of atherogenesis[ J] . J Intern Med,2000, 247(3) : 349 - 358.
  • 2Constantinides P, Chakravarti RN. Rabbit arterial thrombosis production by systemic procedures[J] . Arch Pathol, 1961, 72:197 - 208.
  • 3Abela GS, Picon PD, Friedl SE, et al. Triggering of plaque disruption and arterial thrombosis in an atherosclerotic rabbit model[J]. Circulation, 1995, 91(3): 776- 784.
  • 4Johnstone MT, Botnar RM, Perez AS, et al. In vivo magneticresonance imaging of experimental thrombosis in a rabbit model[J]. Arterioscler Thromb Vasc Biol, 2001,21 (9) : 1556 -1560.
  • 5Nakamura M, Abe S, Kimukawa N. Aortic medial necrosis with or without thrombosis in rabbits treated with Russell's viper venom and angiotensin U [J]. Atherosclerosis, 1997, 128 (2) :149- 156.
  • 6Rekhter MD, Hicks GW, Brammer DW, et al. Animal model that mimics atherosclerotic plaque rupture[J]. Cir Res, 1998,83(7) : 705 - 713.
  • 7yon der Thusen JH, van Vlijmen BJM, Hoeben RC, et al. Induction of atheroselerotic plaque rupture in apolipoprotein E-/-mice after adenovirus-mediated transfer of p53 [J] . Circulation,2002, 105(17) : 2064 - 2070.
  • 8Glagov S, Weisenberg E, Zarins CK, et al. Compensatory enlargement of human atherosclerotic coronary arteries[J]. N Engl J Med, 1987,316(22): 1371- 1375.
  • 9Yamagishi M, Umeno T, Hongo Y, et al. Intravascular ultrasonic evidence for importance of plaque distribution (eccentric vs circumferential) in determining distensibility of the left anterior descending artery[J]. Am J Cardiol, 1997, 79(12) :1596- 1600.
  • 10倪祝华,朱天刚,胡大一,隗冬梅,任文林,王英亮,李清贤.应用血管内超声显像对正常和动脉粥样硬化血管的研究[J].中国超声医学杂志,2000,16(3):161-164. 被引量：12

共引文献58

同被引文献71

  • 1黄继汉,黄晓晖,陈志扬,郑青山,孙瑞元.药理试验中动物间和动物与人体间的等效剂量换算[J].中国临床药理学与治疗学,2004,9(9):1069-1072. 被引量：1591
  • 2仲琳,张运,张梅,季哓平,陈文强,姚桂华,丁士芳,张鹏飞.兔动脉粥样硬化易损斑块模型的建立[J].基础医学与临床,2005,25(4):370-374. 被引量：30
  • 3黄衍寿,莫鸿辉,洪永敦,吴辉.清热解毒法治疗急性冠脉综合征55例[J].广州中医药大学学报,2006,23(1):13-16. 被引量：30
  • 4叶红华,金田秀昭,齐藤滋,塩田方明,田中慎二,宫下裕介,高桥佐枝子,竹田善雄,堂前洋.64层CT与血管内超声对冠状动脉粥样斑块的定性和定量评估的对照研究[J].中华心血管病杂志,2007,35(7):648-651. 被引量：12
  • 5FusterV,Badimon L,Badimon JJ,et al.The pathogenesis of coronary artery disease and the acute coronary syndromes[J].N Engl J Med,1992,326:242-250.
  • 6Shah PK.Plaque disruption and coronary thrombosis:new insight into pathogenesis and prevention[J].Clin Cardio,1997,20(2):38-44.
  • 7Burke AP,Farb A,Malcom GT,et al.Coronary risk factors and plaque morphology in men with coronary disease who died suddenly[J].N Engl J Med,1997,336:1276-1282.
  • 8Naghavim,Libby P,Falk P,et al.From vulnerable plaque to vulnerable patient[J].Circulation,2003,108:1664.
  • 9Virmani R,Burke AP,Kolodgie FD,et al.Pathology of the thin cap fibroatheroma:A type of vulnerable p laque[J].J Interv Cardiol,2003,16(3):267-272.
  • 10Chiesa G,Di Mario C,Colombo N,et al.Development of a lipid-rich,soft plaque in rabbit,monitored by histology and intravascular ultrasound[J].Atherosclerosis,2001,156:277-287.

引证文献6

二级引证文献20

广东医学
2009年 第12期

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