摘要
美国加州大学旧金山分校的伊丽莎白·布莱克本(Elizabeth H.Blackburn)、约翰·霍普金斯医学院的卡罗尔·格雷德(Carol W.Greider)和马萨诸塞州总医院的杰克·绍斯塔克(Jack W.Szostak),因为"发现端粒和端粒酶如何保护染色体",而获得2009年度诺贝尔奖生理学或医学奖。这个结果已在很多人的意料之中。因为端粒和端粒酶的发现揭示了线性染色体末端复制的机制,以及端粒和端粒酶在保护染色体及维持遗传稳定性中的中心作用。端粒和端粒酶的发现为科学家认识并探索衰老和肿瘤的发生机制开辟了新领域,对预防和治疗衰老及与衰老相关的疾病(如肿瘤)具有重要科学和应用意义。
This year＇s Nobel Prize in Physiology or Medicine is awarded to Elizabeth H. Blackburn （University of California in San Francisco）, Carol W. Greider （Johns Hopkins University School of Medicine in Baltimore） and Jack W. Szostak （Massachusetts General Hospital in Boston）. In facts, this was expected by many scientists. Because their discoveries of the telomere and telomerase have solved a major problem in biology： how the linear chromosomes ends can be replicated during each cell divisions and how chromosome ends are protected the genetic integrity of the genome. The discovery of telomere and telomerase, a fundamental mechanism in the cell, has opened a new avenue to our understanding of the biology of aging and cancer, and shed light on the potential new therapeutic strategies for aging and aging-related disease, such as cancer.
出处
《生物物理学报》
CAS
CSCD
北大核心
2009年第5期319-324,共6页
Acta Biophysica Sinica
