摘要
[目的]探讨益气活血解毒法对溃疡性结肠炎(UC)复发患者血浆血栓烷B2(TXB2)和6-酮-前列腺素F1α(6-Keto-PGF1α)水平及TXB2/6-Keto-PGF1α比值的影响。[方法]90例UC复发患者随机分为2组,各45例,治疗组给予益气活血解毒立法的中药汤剂,对照组给予柳氮磺吡啶(SASP)治疗,治疗前后分别检测血浆TXB2、6-Keto-PGF1α水平。[结果]治疗前UC患者血浆TXB2、6-Keto-PGF1α水平及TXB2/6-Keto-PGF1α比值均高于正常人(P<0.01);复发者血浆TXB2、6-Keto-PGF1α水平及TXB2/6-Keto-PGF1α比值均高于未复发者(P<0.01,<0.05)。治疗组治疗后、随访时血浆TXB2、6-Keto-PGF1α水平及TXB2/6-Keto-PGF1α比值均低于对照组(P<0.01,<0.05)。[结论]以益气活血解毒立法的中药对UC复发治疗,与SASP比较,可有效降低血浆TXB2、6-Keto-4-PGF1α水平及TXB2/6-Keto-PGF1α比值,从而阻抑血小板活化,可能是抗UC复发作用机制之一。
[Objective]To investigate influence of increasing pneuma, promoting blood flow and deintoxication on TXB2, 6-Keto-PGF1α and ratio of TXB2/6-Keto-PGF1α in blood plasma of ulcerative colitis recurrence patients. [Methods]Ninety cases with UC recurrence were randomly divided into the treatment group（n=45）and the control group（n=45）according to the random table. The patients of treatment group accepted medicial broth of increasing pneuma, promoting blood flow and deintoxieation treatment. The control group used Salazosulfapyridine. [Results]There were differences between treatment group and control group. Before treatment, the level of TXB2,6-Ke- to-PGF1α and ratio of TXB2,6-Keto-PGF1α in UC group blood plasma was more higher than that in health persons（P〈0.01）;the level in recurrence group was more higher than that in non-recurrence group（P〈0.01 vs P〈0.05）;but after treatment and following up visit, the level in treatment group was more lower than that control group（P〈0. 01 vs P〈0.05）. [Conclusion]The study shows medicial broth of increasing pneuma,promoting blood flow and deintoxication treatment for UC recurrence patients can significantly cut down the level of blood plasma TXB2, 6-Keto-PGF1α and ratio of TXB2/6-Keto-PGF1α than treatment with Salazosulfapyridine. Accordingly the activation of platelet is restrained,and this may be one of contrarelapse mechanismof Chinese medicine.
出处
《中国中西医结合消化杂志》
CAS
2009年第6期351-353,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
国家自然科学基金资助项目(30572390)
