摘要
目的：观察噻氯匹定对急性脑梗死的治疗效果及其对血小板聚集的影响。方法：脑梗死病人１１９例，随机分成噻氯匹定组和基础治疗（右旋糖酐＿４０，三磷腺苷二钠，辅酶Ａ，胞磷胆碱等）对照组，观察疗效，并于治疗前、治疗７ｄ和１６ｄ后检测血小板聚集率。结果：噻氯匹定组有效率达９６％；明显降低血小板聚集率，较对照组有显著性差异。结论：噻氯匹定可用于脑梗死急性期的治疗，抑制血小板聚集是其重要的治疗机制。
AIM: To observe the effect of ticlopidine on platelet aggregation and the clinical efficacy in treating cerebral infarction . METHODS: One hundred and nineteen patients with acute cerebral infarction were divided into 2 groups: 67 patients treated with ticlopidine and 52 patients treated with conventional remedy. The therapeutic effect was observed and the rate of platelet aggregation was measured. RESULTS: The clinical effective rate of ticlopidine was 96%. There was an inhibition of platelet aggregation in ticlopidine group compared with control group. CONCLUSION: Ticlopidine is effective for treating acute cerebral infraction and decreasing the rate of platelet aggregation.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
1998年第6期323-324,共2页
Chinese Journal of New Drugs and Clinical Remedies
关键词
噻氯匹定
脑梗塞
血小板聚集
药物疗法
ticlopidine
cerebral infarction
platelet aggregation
dextrans
adenosine triphosphate
coenzyme A
cytidine diphosphate choline
