摘要
在衡量单个细胞力学行为的研究中,越来越多地采用结合实验的数值模拟方法。在连续介质力学框架下,发展了一种新的心肌细胞本构模型,并与微管吮吸实验结合,探讨了心肌细胞的力学特性。本构模型是对普遍使用的仅能用于小变形分析的标准线性固体模型的一种扩展,它将超弹性性能引入到黏弹性模型中,用以描述细胞的大变形黏弹性效应。基于改进的本构模型,对心肌细胞微管吮吸实验过程进行了有限元模拟,并将计算结果与实验结果以及经典理论解进行了对比。结果显示发展的本构模型适合细胞大变形问题的有限元数值模拟。
Numerical modeling with experimental analysis is increasingly being used to evaluate the mechanical properties of living cells in single cell mechanics. In the present study, through the continuum mechanics process, a new constitutive model for cardiac myocyte is developed, and together with the micropipette aspiration experiment, the mechanical property of cardiac myocyte is investigated. The commonly used standard linear solid model is extended into a nonlinear viscoelastic constitutive model in which was introduced the hyperelasticity to describe the large deformation of myocytes in response to micropipette aspiration. Based on the constitutive model and experiment data, the experiment process is simulated, and the computational results are compared with the experiment results and classic theoretical solutions. The results show that the new constitutive model suits the computation of large deformation of ceils.
出处
《力学学报》
EI
CSCD
北大核心
2009年第6期913-919,共7页
Chinese Journal of Theoretical and Applied Mechanics
关键词
心肌细胞
大变形
非线性黏弹性本构
微管吮吸实验
数值模拟
cardiac myocyte, large deformation, nonlinear viscoelasticity constitutive model, micropipette aspiration, numerical simulation
