摘要
为探讨充血性心力衰竭（ＣＨＦ）患者血浆内皮素－１（ＥＴ－１）的变化及倍他乐克（Ｂｅｔａｌｏｃ）对之影响，采用放射免疫法及高效液相色谱法测定４３例ＣＨＦ患者血浆ＥＴ－１和去甲肾上腺素（ＮＥ）水平。４３例中２４例用倍他乐克＋常规治疗，１９例用常规治疗，疗程１月。结果表明：ＣＨＦ患者治疗前血浆ＥＴ－１和ＮＥ均显著升高，且与ＣＨＦ程度呈正相关；治疗后降低。
To investigate the alterations of plasma endothelin 1(ET 1) in patients with congestive heart failure(CHF) and the effects of metoprolol on it, plasma ET 1 and norepinephrine(NE) were measured in 43 patients using radioimmunoassay and high performance liquid chromatography methods. Twenty four patients were treated with metoprolol plus the routine therapy while the others were received the routine therapy only. The findings were that levels of plasma ET 1 and NE increased before the treatment, and decreased after the treatment with metoprolol for 1 month. There was no alteration of plasma ET 1 or NE in the control group.
出处
《湖南医科大学学报》
CSCD
1998年第5期467-469,共3页
Bulletin of Hunan Medical University
关键词
心力衰竭
内皮素
倍他乐克
充血性
药物疗法
heart failure
endothelin
norepinephrine
metoprolol
therapeutical use
