摘要
由食物引起湿疹、变应性鼻炎、外源性哮喘，在临床上较为常见。经典的理论，从抗原抗体反应角度，更注重其中大分子成份，尤其是蛋白质。然而，仍有研究表明饮食中脂类和其代谢产物，也发挥十分重要的作用。特应性疾病具有遗传倾向，类似的病理生理，血清ＩｇＥ水平升高，对拮抗剂、激素较好的治疗效果等。它们可能是同一个疾病的不同表现。从细胞生物学分析，受遗传、胃肠道功能强弱等因素的影响，长期较高脂的饮食结构，可以使膜脂质成份改变，进而出现细胞的某些生化反应增强。在临床上呼吸道表现为鼻和支气管的高反应性；在皮肤表现为：皮肤血管和汗腺对刺激过份敏感。不合理的脂肪比例可诱发某酶（如磷脂酶Ａ２）活性增强，导致机体的脂类代谢紊乱，可以出现异常的脂类和变态反应的活性因子。所以饮食脂类在特应性疾病的早期形成和发病过程中。
It is common that food induces eczema, allergic rhinitis and asthma. According to classic theory, in view of reaction of antigen and antibody, much attention were paid to large molecule elements, especially to proteins. However, some research showed that lipid in diet and its metabolic products played an important role in atopic diseases. Atopic diseases have a hereditary tendency. They have a similar pathophysiology,with a elevated serum IgE and have better effects when treated with steroid drugs. Affected by heredity and digestive function,if higher lipid of diet is taken for a long time, cell membrance structure will change. Thus some biochemical reactions increase. Nonreasonable fat ratio in diet can induce the increase in some enzyme activities such as phospholipase A 2, resulting in disorder of lipid metabolism. As a result, abnormal lipids and allergic activity factors appear. Therefore,lipids in diet play an important role in atopic diseases.
出处
《广东药学院学报》
CAS
1998年第4期295-299,共5页
Academic Journal of Guangdong College of Pharmacy
关键词
饮食
特应性疾病
脂类代谢紊乱
atopic disease
diet
lipid
eczema
allergic rhinitis
asthma
