摘要
利用硅胶、Sephadex LH-20及半制备HPLC等柱色谱方法从菊科鸦葱属植物蒙古鸦葱Scorzonera mongolica Maxim.的甲醇提取物中分离得到2个化合物,根据理化性质和光谱数据鉴定其结构分别为3β-十二酰高根二醇(1)和3β-十四酰高根二醇(2)。其中,化合物1为新化合物,2为新天然产物。体外细胞毒活性显示化合物1和2对人肺癌细胞A-549显示一定的细胞毒活性。
Two erythrodiol triterpene fatty esters, 3β-dodecanoyl erythrodiol （1） and 3β-tetradecanoyl erythrodiol （2）, were isolated from Scorzonera mongolica. Their structures were elucidated on the basis of IR, MS and extensive 2D NMR spectroscopic analysis. Compound 1 was identified to be a new compound and 2 was confirmed to be a new natural compound. Their antitumor effects in vitro were evaluated with MTT and SRB assays, but compounds 1 and 2 only showed moderate cytotoxicities on A-549 cell line.
出处
《药学学报》
CAS
CSCD
北大核心
2009年第11期1258-1261,共4页
Acta Pharmaceutica Sinica
基金
supported by the National 863 project (2007AA091701)
Natural Science Foundation of Zhejiang (Y2080579)
Important Project of Zhejiang Ocean University (21135030107)
关键词
蒙古鸦葱
高根二醇
三萜脂肪酸酯
Scorzonera mongolica
erythrodiol
triterpene fatty ester
