摘要
目的:探讨肝硬化患者腰椎、股骨骨密度的改变以及肝功能、血钙、血磷、体质量指数(BMI)等相关因素的关系.方法:102名受试者分为两大组:肝硬化组60例,其中Child-Pugh A级22例,B级18例,C级20例;正常对照组42例,两组均同步检测其腰椎、股骨骨密度Ca2+、P3+及胆碱脂酶.另外收集肝硬化患者的年龄、BMI以及肝功能等指标.结果:肝硬化组腰椎、股骨骨密度均较对照组明显降低(P<0.05或0.01).Child C腰椎骨密度较对照组、Child A级差异明显,统计学有显著性差异(0.851±0.207vs1.070±0.22,1.036±0.192,均P<0.05).肝硬化患者的腰椎、股骨骨密度均与BMI有直线相关性(r=2.3,2.418,均P<0.05),同时腰椎骨密度还与胆碱酯酶有直线相关性(r=2.734,P<0.05).结论:慢性肝硬化患者腰椎骨密度的改变比股骨明显;胆碱酯酶反应了肝脏的储备能力与肝脏损害的程度,一定程度上可预测肝硬化腰椎骨密度是否改变.
AIM：To observe changes in bone mineral density （BMD） of the femur and lumbar spine in patients with liver cirrhosis and analyze factors potentially correlated with such changes. METHODS：Sixty liver cirrhosis patients,of which 22 had Child-Pugh A liver function,18 had Child-Pugh B,and 20 had Child-Pugh C,and 42 healthy volunteers were included in the study. The BMD of the femur and lumbar spine as well as serum calcium （Ca2＋）,inorganic phosphate （P3＋） and cholinesterase （CHE） were simultaneously measured in both groups. Other parameters such as age,body mass index （BMI） and liver function were also recorded. RESULTS：The BMD of the femur and lumbar spine was significantly lower in liver cirrhosis patients than in normal controls （P〈0.05 and 0.01,respectively）. The BMD of the lumbar spine was significantly lower in patients with ChildPugh A liver function than in normal controls and patients with Child-Pugh C liver function （0.851 ± 0.207 vs 1.070 ± 022 and 1.036 ± 0.192,respectively; both P〈0.05）. A linear correlation was noted between the BMD of the femur and lumbar spine and BMI （r = 2.3 and 2.418,respectively; both P〈0.05） as well as between lumbar BMD and CHE （r = 2.734,P〈0.05）. CONCLUSION：The change in the BMD of the lumbar spine was more significant than that in the BMD of the femur in patients with liver cirrhosis. CHE may predict,to some extent,the change in lumbar BMD.
出处
《世界华人消化杂志》
CAS
北大核心
2009年第27期2850-2853,共4页
World Chinese Journal of Digestology
关键词
肝硬化
骨密度
血钙
胆碱酯酶
Liver cirrhosis Bone mineral density Serum calcium Cholinesterase
