摘要
Systemic lupus erythematosus (SLE) is an archetypical systemic,autoimmune inflammatory disease,of which the mechanism still not unveiled. Studies on epigenetics in SLE have long been the subject of investigation and as part of epigenetics. DNA methylation has been confirmed to play a role in the pathogenesis of SLE. The high autoreactivity of CD4+T cell from SLE patients is associated with DNA hypomethylation. DNA hypomethylation is crucial to induce SLE-like autoimmune disease in SLE-non-susceptible mice. The reactivation of inactive X chromosome by hypomethylation may lead to high incidence of SLE in women. Drug-induced SLE is also connected with DNA hypomethylation. To understand the role of DNA methylation in the onset of SLE comprehensively,we review the findings reported in the literatures about DNA methylation and SLE.
Systemic lupus erythematosus （SLE） is an archetypical systemic, autoimmune inflammatory disease, of which the mechanism still not unveiled. Studies on epigeneties in SLE have long been the subject of investigation and as part of epigenetics. DNA methylation has been confirmed to play a role in the pathogenesis of SLE. The high autoreactivity of CD4 ＋ T cell from SLE patients is associated with DNA hypomethylation. DNA hypomethylation is crucial to induce SLE - like autoimmune disease in SLE - non - susceptible mice. The reactivation of inactive X chromosome by hy- pomethylation may lead to high incidence of SLE in women. Drug - induced SLE is also connected with DNA hypomethylation. To understand the role of DNA methylation in the onset of SLE comprehensively, we review the findings reported in the literatures about DNA methylation and SLE.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2009年第11期2217-2220,2224,共5页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(No.30471613)
上海市科委重点资助项目(No.06JC14050)
上海市科委优秀学科带头人计划资助项目(No.07XD14021)
