摘要
用酶联免疫吸附方法（ELISA）检测糖尿病脑梗死组、非糖尿病脑梗死组、糖尿病非脑梗死组、健康对照组的基质金属蛋白酶9（MMP-9）、组织基质金属蛋白酶抑制物1（TIMP-1）的水平。结果显示糖尿病脑梗死组MMP-9、TIMP-1水平明显明显高于其他3组（P〈0．05），提示其可能在糖尿病脑梗死发病过程中有重要作用。
The serum levels of matrix metalloproteinase-9 （ MMP-9 ） and tissue inhibitors of matrix metalloproteinase-1 （TIMP-1）were measured in patients with cerebral infarction and type 2 diabetes mellitus, cerebral infarction patients without type 2 diabetes mellitus, diabetes mellitus patients without cerebral infarction, and healthy people. The results showed that the levels of MMP-9 and TIMP-1 in cerebral infarction patients with type 2 diabetes mellitus was significantly higher than those in other three groups（P 〈0.05 ） , suggesting that MMP- 9 and TIMP-1 may play important roles in the development of cerebral infarction in patients with type 2 diabetes mellitus.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2009年第5期526-527,共2页
Chinese Journal of Endocrinology and Metabolism
关键词
糖尿病
脑梗死
基质金属蛋白酶9
金属蛋白酶抑制物1
Diabetes mellitus
Cerebral infarction
Matrix metalloproteinase-9
Tissue inhibitors of matrix metalloproteinase-1
