摘要
目的:研究孕妇产前凝血、抗凝、纤溶指标的变化及其临床意义。方法:测定220例临产孕妇凝血指标:血浆凝血酶时间(TT)、血浆活化部分凝血活酶时间(APTT)、血浆凝血酶原时间(PT)、血浆纤维蛋白原含量(FIB);抗凝指标:抗凝血酶Ⅲ(AT-Ⅲ);纤溶指标:纤维蛋白降解产物(FDP)、D-二聚体(D-D)。并与非孕健康妇女对照组(85例)作比较。结果:临产孕妇组:TT、APTT、PT、PT-INR、FIB、AT-Ⅲ、FDP、D-D分别为(19.23±2.56)s、(31.83±3.66)s、(12.34±0.51)s、0.96±0.046、(4.88±0.66)g/L、(179.48±54.2)mg/L、(5.32±0.59)mg/L、(0.53±0.318 mg/L;非孕健康妇女对照组:TT、APTT、PT、PT-INR、FIB、AT-Ⅲ、FDP、D-D分别为(18.03±2.11)s、(30.16±1.75)s、(13.71±0.42)s、1.10±0.039、(3.06±0.29)g/L、(230.23±50.25)mg/L、(4.06±0.51)mg/L、(0.38±0.105)mg/L。以上各指标经统计学处理后,除APTT在两组间无差异(P>0.05)外,其余各项指标在组间差异上均有统计学意义(P<0.01)。结论:分析显示:临产孕妇抗凝活性减弱,凝血、纤溶活性增强,临产前孕妇作凝血、抗凝、纤溶指标测定对防治产后大出血等产科意外具有指导意义,从而确保母婴健康,降低合并病理产科发生率。
Objective：To evaluate the clinical signification of the variation of coagulation indexes,anticoagulant indexes,fibrinolysis indexes in normal pregnancy women.Methods：The levels of plasma prothrombing time（PT）,activated partial thromboplasting time （APTT）,plasma thrombin time（TT）,fibrinogen（FIB）,antithrombin-Ⅲ（AT-Ⅲ）,fibrinogen degradation product （FDP）,D-dimer（D-D）in 220 health pregnancy women and 85 non-pregnant health women were measured.The correlation analysis of the results of severe items was made.Results：For the pregnancy women,the levels of plasma TT were （19.23±2.56）s,APTT were（31.83±3.66）s,PT were（12.34±0.51）s,PT-INR were（0.96±0.046）,FIB were（4.88±0.66）g/L,AT-Ⅲ were（179.48±54.21）mg/L,FDP were（5.32±0.59）mg/L,D-D were（0.53±0.318）mg/L;For the Non-pregnant women,the levels of plasma TT were（18.03±2.11）s,APTT were （30.16±1.75）s,PT were（13.71±0.42）s,PT-INR were（1.10±0.039）,FIB were（3.06±0.29）g/L,AT-Ⅲ were（230.23±50.25）mg/L,FDP were （4.06±0.51）mg/L,D-D were 90.38±0.105）mg/L.The results were analyzed with the correlation,The levels of plasma TT,PT,PT-INR,FIB,AT-Ⅲ,FDP,D-D had significant difference between the two group women（P〈0.01）,except APTT（P〉0.05）.Conclusions：The activity of coagulation and fibrinolysis of the prognancy women in labor were enhance,the activity of anticoagulant were weaken.Detecting the levels of coagulation indexes,anticoagulant indexes,fibrinolysis indexes can prevent the postpartum hemorrhage and ensure the health of pregnancy women and reduce the incidence of the complications.
出处
《中国医药导刊》
2009年第11期1916-1917,共2页
Chinese Journal of Medicinal Guide
关键词
产前孕妇
凝血
抗凝
纤溶
Coagulation
Anticoagulant
Fibrinolysis
