摘要
目的本研究旨在探讨Ki67在膀胱癌中的表达与膀胱癌的侵袭,转移及预后的关系。方法用免疫组化SP法检测154例膀胱癌组织中Ki67的表达。结果Ki67在126例肿瘤组织中有阳性表达,阳性率为81.8%。Ki67在膀胱癌组织的表达与肿瘤病理分级,T分期,远处转移呈正相关(P<0.05)。结论Ki67可能参与了膀胱癌的侵袭与转移,Ki67可做为预后判断因子,结合病理分级和临床分期分析能提高对膀胱癌患者预后判断的准确性。
[ Objective ] This study was to investigate the correlations of Ki67 expressions in tumor to metastasis, invasion, and prognosis of bladder cancer. [Methods] Expressions of Ki67 in 154 specimens of bladder cancer were detected by SP immunohistochemistry. [Result] Positive rate of Ki67 was 81.8% in bladder cancer tissues. Ki67 staining in cancer tissue was positively related with pathologic grade and T stage and distant metastasis （P 〈0.05）. [ Conclusions ] Ki67 maybe participate in invasion and metastasis of bladder cancer. Ki67 may be an prognostic factor and, when used in combination with pathologic grading and clinical staging, may increase accuracy of predicting prognosis of patients with bladder cancer.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2009年第19期3008-3010,共3页
China Journal of Modern Medicine
