摘要
目的评价氨氯地平联用小檗碱治疗轻、中度老年高血压合并痛风患者的降压疗效。方法选择轻、中度老年高血压患者26例,给予患者口服氨氯地平5mg,1次/d,小檗碱0.3g,3次/d,同时给予急性痛风患者,口服秋水仙碱0.5mg,慢性痛风患者,口服别嘌呤醇100mg。观察患者服药后舒张压(DBP)、收缩压(SBP)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)及高密度脂蛋白胆固醇(HDL-C)等指标的变化。结果26例患者治疗8周后,DBP及SBP分别从(104±5)和(166±8)mmHg下降至(83±3)和(131±7)mmHg;治疗前后差异有显著性(P<0.O5)。治疗前后TC、TG、LDL-C及HDL-C等治疗差异亦有显著性(P<0.05)。结论氨氯地平联用小檗碱治疗轻、中度老年高血压合并痛风患者,在短期内可有效降低DBP与SBP,临床疗效显著,不良反应发生率低。
Objective To investigate the efficacy and safety of amlodipine with berberine in the treatment of mild and moderate hypertensive with arthrolithiasis.Methods 26 cases were treated by oral administration of amlodipine 5 mg,berberine 0.3g,meanwhile treated the acute arthrolithiasis by oral administration of colchicine 0.5mg,reated hypertensive with chronic gout by oral administration of allopurinol 100mg.DBP、SBP、 TC、TG、LDL-C and HDL-C were observed 8 weeks after treatment.The clinical efficacy was observed. Results In 26 cases, the average DBP and SBP of patients declined from （ 104 ± 5 ） and （ 166 ±8 ） mmHg to （ 83 ± 3 ） and （ 131 ± 7 ） mmHg, respectively （ P 〈 0.05 ）. TC, TG, LDL - C and HDL - C increased significantly after 8 weeks treatment compared with before treatment. （ P 〈 0.05 ）. Conclusion It is quick and safe. Little side - effect can be observed using amlodipine with berberine in treating mild and moderate hypertensive with arthrolithiasis.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2009年第11期2895-2896,共2页
Lishizhen Medicine and Materia Medica Research
关键词
氨氯地平
小檗碱
高血压病
痛风
Amlodipine
Berberine
Hypertensive
Arthrolithiasis
