摘要
幽门螺杆菌（ＨＰ）是慢性活动性胃炎、消化性溃疡致病菌，胃（ＭＡＬＴ）淋巴瘤的致病因子，亦可能是胃癌协同致癌因子，与功能性消化不良的关系有待明确，与其他疾病也有关联。ＨＰ致病主要依靠其在胃粘膜的定居能力和致病因子，很可能是胃粘膜免疫反应的结果。血浆和胃液的生长抑素和表皮生长因子含量下降，粘液结构的破坏、脱落，以及胃粘膜血流量下降等促使溃疡发生。长期慢性炎症导致肠化，异型增生直至胃癌，细胞的异常增殖、凋亡，以及癌基因的过度表达，抑癌基因的缺失等，增加了胃癌发生的危险性。
HP is the germ of chronic active gastritis,the pathogenetic factor of peptic ulcer and MALT,and perhaps the germ of gastric cancer.It also has some connections with function dyspepsia and other diseases.HP can cause diseases mainly because of its settled ability in gastric mucosa and pathogenetic factor which probably make gastric mucosa lose its immunity.The decrease of somatostation and epidermal growth factor in plasma and gastric juice,the destruction and drop of the viscous structure,and the decrease of gastric mucosa’s volume of blood flow bring about the ulcer.The long term chronic inflammation will lead to intestinal metaplasia,unusual proliferation and even gastric cancer.The unusual breed and apoptosis of bacteria,the over expression of cancer factor and the lack of the restrain cancer gene will increase the possibility of gastric cancer.
