摘要
方法：实验用４８只大鼠打击致瘫，其中治疗组２４只在伤后３０分钟注射利多卡因（１５ｍｇ／ｋｇ），以后每天一次。对照组不投药。全部动物分别于伤后第５天、第８天处死并取脊髓标本送检验。结果：实验组动物２４只中有２０只恢复了痛觉和４级运动功能，对照组２４只动物没有功能恢复（Ｐ＜００１）。化验显示，自由基反应产物对照组明显高于实验组（Ｐ＜００１）。结论：结果表明：１利多卡因对脊髓有保护作用；２自由基参与了药理作用。
Methods:48 rats were paralysed by hit.30 minutes after injury, 24 animals in treated group were injected with lidocaine (1.5mg/kg) once a day. All animals were sacrificed depree and spinal cord removed for analysis after 5 days, 8 days respactively.Results:The sense of pain and IV motility of 24 animals in treated group recovered ,and paraplegia didn't vary in contral group (P<001);product level of free radical reaction of contral animals was higher than treated group,(P<001).Conclusion:The spinal cord was protected by lidocaine and free radical was involved in it.
出处
《颈腰痛杂志》
1998年第3期179-180,共2页
The Journal of Cervicodynia and Lumbodynia
关键词
脊髓损伤
利多卡因
自由基鼠
spinal cord injury
Lidocaine
free radical
rat
