摘要
目的：探讨短暂性脑缺血发作（ＴＩＡ）病人事件相关电位（ＥＲＰ）的变化规律及其临床意义。方法：用听觉Ｏｄｄｂａｌ刺激序列ＥＲＰ、认知能力筛选试验（ＣＣＳＥ）和简易智力状态试验（ＭＭＳＥ）检测３２例ＴＩＡ病人和３０例年龄、性别、利手和教育程度相匹配的正常人。结果：病人组ＥＲＰ的Ｎ２和Ｐ３峰潜伏期较对照组显著延长（Ｐ＜０．０１），Ｎ２和Ｐ３波幅两组均无显著性差异，Ｐ３峰潜伏期（Ｐ３ＰＬ）异常率为２５％。病人组ＭＭＳＥ较对照组低（Ｐ＜０．０５），但与Ｐ３ＰＬ未见有相关性（ｒ＝－０．２４４，Ｐ＞０．１）；ＣＣＳＥ与对照组无显著差异，但与Ｐ３ＰＬ呈显著负相关（ｒ＝－０．４７３，Ｐ＜０．０１）。结论：ＴＩＡ病人存在不同程度的认知功能障碍。对认知功能障碍的早期发现。
Objectives: To investigate the changes of auditory event-related potentials (ERPs) and the clinical value in patients with transient ischemic attack (TIA). Methods:Auditory ERP, cognitive capacity screening examination (CCSE) and mini-mental state examination (MMSE) were studied separately in 32 patients with TIA and 30 normal subjects matched with age, sex, handedness and education.Results: As compared with the control group, the peak latencies of N_2 and P_3 components of ERP were significantly delayed (P<0.01) and the amplitudes of N_2 and P_3 didn′t show significant difference. The abnormality rate of P_3 peak latency (P_3 PL) was 25%. MMSE in patient group was lower (P<0.05) than that in control group and no significant correlation between MMSE and P 3PL (r=0.244,P<0.1) was noted. No significant difference was observed in CCSE between two groups. However, CCSE showed an apparent negative correlation (r=0.473,P<0.01) with P3 PL.Conclusions: Cognitive dysfunction to some extent exists in TIA patients. ERP might be of clinical importance in detecting the cognitive dysfunction early stage.
关键词
短暂性
脑缺血发作
事件相关电位
认知功能
Transient ischemic attack Event-related potentials Cognitive function
