摘要
目的：探讨无临床症状的缺铁性贫血（ＩＤＡ）小学生（分为补铁组和安慰组）治疗前后认知功能的改变。方法：采用智商（ＩＱ）、事件相关电位（ＥＲＰ）测试的方法对７０例ＩＤＡ、３０例正常小学生的认知功能进行对照测查。结果：与正常对照组比，两组ＩＤＡ儿童治疗前Ｐ３００潜伏期均明显延长，治疗３个月后补铁组Ｈｂ升高１０ｇ／Ｌ以上，复查ＥＰＲ，补铁组Ｐ３００潜伏期恢复，与治疗前比较差异有极显著意义（Ｐ＜００２），而与正常组比无统计学差异（Ｐ＞００５）。结论：Ｐ３００是客观评定儿童认知功能的敏感指标。
Objectives:To study the changes of the cognitive function of school-agers (7-12 years old)with asymptomatic iron deficiency anemia (IDA) before and after treatment.Methods:The cognitive function of 70 cases with IDA and 30 normal school-agers were studied by means of IQ and event-related potential (ERP) determination.Results:As compared with the normal group, it was noted that the latencies of P300 of children with IDA in both groups were remarkably prolonged prior to iron replacement. Hemoglobin was increased by more than 10g/L and the latencies of P300 restored apparently. There was a significant (P<0.002) difference between pre-treatment and post-treatment.Howerer,no statistical difference was noted (P<0.002) as compared with the control group.Conclusions:It was suggested that P300 might be a sensitive and objective index in evaluating the cognitive function and might detect early the subclinical damage to the nervous system due to IDA. The therapeutic effect could be observed as well.
基金
卫生部"八五"重点攻关科研课题
