摘要
目的研究靶控芬太尼、瑞芬太尼、舒芬太尼对全麻患者罗库溴铵肌松作用起效、维持和恢复时间的影响。方法45例神经外科择期手术患者,年龄20～60岁,ASAⅠ或Ⅱ级,随机分成3组(n=15):芬太尼复合异丙酚组(F组),瑞芬太尼复合异丙酚组(R组)和舒芬太尼复合异丙酚组(S组)。3组患者诱导分别采用血浆靶浓度芬太尼4ng/ml、瑞芬太尼4ng/ml和舒芬太尼0.4ng/ml复合异丙酚血浆靶浓度4mg/ml靶控输注。静脉注射罗库溴铵0.6mg/kg(2×ED95)后,观察并记录3组起效时间、维持时间、恢复指数及呛咳、肢体抽动等插管反应。结果3组间年龄、性别等一般资料无显著差异,F组起效时间为(78.6±19.8)s,维持时间为(30.2±8.9)min;R组起效时间为(81.0±20.1)s,维持时间为(29.9±11.1)min;S组起效时间为(82.2±15.6)s,维持时间为(32.6±8.3)min。3组肌松起效时间比较差异无统计学意义(P>0.05),3组肌松维持时间和恢复指数比较差异也无统计学差异(P>0.05),3组均无呛咳等插管反应。结论术中靶控输注舒芬太尼对罗库溴铵的肌松作用无影响。
Objective To evaluate the effect of sufentanil given by target-controlled infusion （TCI） on the rocuronium-induced neuromus- cular block during general anesthesia with propofol. Methods Forty-five ASA Ⅰ or Ⅱpatients undergoing neurosurgery under general anesthesia were randomly divided into 3 groups （n = 15 ） ： fentanyl ＋propofol （F） group ; remifentanil ＋propofol （R） group ; sufentanil ＋propofol （S） group. Neuromuscular block （N-M block） was monitored using train-of four （TOF） stimulation by recording the force of contraction of adductor pollicis muscle with a muscle relaxation monitor （TOF WATCH SX）. Results The three groups were respectively induced and maintained with the TCI of fentanyl （target plasma concentration at 4 ng/ml ）, remifentanil （target plasma concentration at 4 ng/ml ）, sufentanil （target plasma concentration at 0.4 ng/ml ） combined with propofol （target plasma concentration at 4 ng/ml ）. Rocuronium 0.6mg/kg was given intravenously to facilitate tracheal intubation. The onset time,the duration of neuromuscular blockade and the recovery index were recorded. Results the onset time of N-M block was comparable among the three groups range from 76 to 82 seconds. There was no significant difference in the ＇above parameters among the three groups. Conclusion TCI of sufentanil has no effect on rocumnium induced N-M block.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2009年第9期698-699,719,共3页
Journal of China Medical University
