期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

结核分枝杆菌ESX分泌系统研究进展 被引量：5

原文传递
导出
摘要 在结核分枝杆菌中存在能够使某些蛋白通过其高度疏水和通透性极差的细胞壁的分泌系统，其中ESX-1分泌系统负责ESAT-6（early secreted antigenic target of 6 kD）和CFP-10（culture filtrate protein of 10kD）的分泌．这两种蛋白能够形成1：1的二聚体结构，并且是结核分枝杆菌重要的毒力因子．近年来陆续发现其他一些蛋白也由ESX-1分泌系统所分泌．在结核分枝杆菌中还存在其他4种类似ESX-1的分泌系统ESX-2～ESX-5．ESX分泌系统也在其他革兰氏阳性菌和放线菌中被发现，有学者按照公认的术语称其为Ⅶ型分泌系统．本文综述了结核分枝杆菌ESX分泌系统的组成和分子机制，以及分泌蛋白与宿主的相互作用等方面的研究进展．
作者 李浩 徐俊杰 陈薇
机构地区 军事医学科学院微生物流行病研究所
出处 《中国科学（C辑）》 CSCD 北大核心 2009年第10期925-932,共8页 Science in China(Series C)
基金 国家自然科学基金(批准号:30571745和30972772)资助项目
关键词 结核分枝杆菌 ESX—1 ESAT-6 CFP-10
分类号 Q935 [生物学—微生物学]
  • 相关文献

参考文献1

二级参考文献40

  • 1WHO Global tuberculosis contol-surveillance,planning,financing.[online]http://www.who.int/tb/publications/global_report/2008/en/index.html.
  • 2Wells C D,Ceqielski J P,Nelson L J,et al.HIV infection and multidrug-resistant tuberculosis:the perfect storm.J Infect Dis,2007,196(Suppl 1):S86-S107.
  • 3Lewis K N,Liao R,Guinn K M,et al.Deletion of RD1 from mycobacterium tuberculosis mimics bacilli Calmette-Guerin attenuation.J Infect Dis,2003,187(1):117-123.
  • 4Sherman D R,Guinn K M,Hickey M J,et al.Mycobacterium tuberculosis H37Rv:Delta RD1 is more virulent than M bovis bacille Calmette-Guerin in long-term murine infection.J Infect Dis,2004,190(1):123-126.
  • 5Renshaw P S.Panagiotidou P,Whelan A,et al.Conclusive evidence that the major T cell antigens of the Mycobactedum tuberculosis complex ESAT-6 and CFP-10 from a tight.1:1 complex and characterization of the structural properties of ESAT-6.CFP-10 and the ESAT6-CFP10 complex:implication for pathogcnesis and virulence.J Biol Chem,2002,277(24):21598-21603.
  • 6Stanley S A,Raghavan S,Hwang W W,et al.Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system.Proc Natl Acad Sci USA 2003,100(22):13001-13006.
  • 7Champion P A.Stanley S A,Champion M M,et al.C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis.Science,2006,313(5793):1583-1584.
  • 8Okkels L M,Brock I,Follmann F,et al.PPE protein(Rv3873)from DNA segment RD-1 of Mycobaeterium tuberculosis:strong recognition of both specific T-cell epitopes and epitopes conserved within the PPE family.Infect Immun,2003,71(11):6116-6123.
  • 9Pym A S.Brodin P,Brosch R,et al.Loss of RD-1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti.Mol Microbiol,2002,46(3):709-717.
  • 10Berthet FX,Rasmussen PB,Rosenkrands I,et al.A Mycobacterium tuberculosis operon encoding ESAT-6 and a novellow-molecular-mass culture filtrate protein(CFP-10).Microbiology,1998,144(pt 11):3195-3203.

共引文献7

同被引文献70

  • 1Lee P A, Tullman-Ercek D, Georgiou G. The bacterial twin- arginine translocatioa pathway[ J ]. Annu Rev Microbiol, 2006, 60 ( 373-395.
  • 2De Leeuw E, Porcelli I, Sargent F, et al. Membrane interactions and self-association of the TatA and TatB components of the twin- arginine translocation pathway[ J ]. FEB S Lett, 2001, 506 (2) : 143-148.
  • 3lze B, Stanley N R, Buchanan G, et al. Role of the Eschericbia coli Tat pathway in outer membrane integrity[ J]. Mol Miernbiol, 2003, 48(5) : 1183-1193.
  • 4Sargent F, Stanley N R, Berks B C, et al. Sec-independent protein translocation in Escherichia eoli. A distinct and pivotal role for the TatB protein[J]. J Biol Chem, 1999, 274 (51) : 36073 -36O82.
  • 5DeLisa M P, Lee P, Palmer T, et al. Phage shock protein PspA of Escherichia coli relieves saturation of protein export via the Tat pathway[J]. J Bacteriol, 2004, 186(2): 366-373.
  • 6Alami M, Trescher D, Wu L F, et al. Separate analysis of twin- arginine translocation (Tat)-specific membrane binding and translocation in Escherichia coli [ J ]. J Biol Chem, 2002, 277 ( 23 ) : 20499-20503.
  • 7Ruiz N, Silhavy T J. Sensing external stress: watchdogs of the Eseheriehia coil cell envelope[ J]. Curr Opin Mierobiol, 2005,8 (2) : 122-126.
  • 8Stanley N R, Palmer T, Berks B C. The twin arginine consensus motif of Tat signal peptides is involved in Sec-independent protein targeting in Escherichia coli[ J]. J Biol Chem, 2000, 275 (16) : 11591-11596.
  • 9Ignatova Z, Hornle C, Nurk A, et al. Unusual signal peptide directs penicillin amidase from Escherichia coli to the Tat translocation machinery [ J]. Biochem Biophys Res Commun, 2002, 291( 1 ) : 146-149.
  • 10Dilks K, Rose R W, Hartmann E, et aL Prokaryotic utilization of the twin-arginine translocation pathway: a genomic survey[J]. J Bacteriol, 2003, 185(4) : 1478-1483.

引证文献5

二级引证文献7

中国科学（C辑）
2009年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部