摘要
缺血/再灌注损伤是临床常见的一种病理生理过程。缺血后处理是长时间缺血后,于再灌注前短时间内进行反复短暂的再灌和停灌,可明显减轻缺血组织和器官的再灌注损伤。药物后处理指在长时间缺血后,于再灌注前或再灌注开始的几分钟内用药,通过药物干预来减轻器官的再灌注损伤。其保护作用机制与缺血预处理、缺血后处理相似,但药物后处理更具有临床应用价值,为器官再灌注损伤的治疗提供了新策略。
Ischemia/reperfusion injury is a familiar pathophysiological process in clinic. Ischemic posteonditioning applied at the onset of reperfusion following a specific prescribed algorithm is a series of brief mechanical interruptions of reperfusion, and affords protection in vivo. Pharmacological postconditioning which is defined as medicine administration before reperfusion or in the early minitues of reperfusion is a pattern against organ ischemia-roperfusion injury, Pharmacological postconditioning has similarly protective mechanism with ischemic preconditioning（ IPC ）and ischemic postconditioning（ I-PostC ）. Compared to IPC and I-PostC, Pharmacological postconditioning is more worth of clinical application, and may provide a new therapy strategy for organ reperfusion injury.
出处
《医学综述》
2009年第21期3207-3209,共3页
Medical Recapitulate
关键词
器官缺血
药物后处理
缺血后处理
再灌注损伤
Organ isehemia
Pharmacological postconditioning
Ischemic postconditioning
Reperfusion injury
