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紫杉醇联合化疗对晚期胃癌患者血清细胞因子水平影响

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摘要 目的观察紫杉醇联合顺铂方案(DP方案)对晚期胃癌患者的近期疗效及血清细胞因子水平影响。方法对54例晚期胃癌患者采用DP联合化疗方案,两个疗程后观察疗效和患者血清细胞因子水平变化。结果完全缓解(CR)3例,部分缓解(PR)26例,稳定25例,总有效率53.7%;主要毒性反应为白细胞减少43例(79.6%)、血红蛋白降低31例(57.4%)、脱发32例(85.2%)、肌肉关节痛24例(44.4%)等,无治疗相关性死亡;化疗后患者血清IL-2、TNF-α和IFN-γ明显升高(P<0.01),分别为(68.8±10.5)、(59.4±16.2)和(22.4±13.4)U/mL。结论紫杉醇联合顺铂方案(DF方案)能够改善晚期胃癌患者细胞免疫功能,近期疗效显著,且未增加毒副反应。
出处 《中国医药指南》 2009年第21期39-40,共2页 Guide of China Medicine
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