摘要
通过癸二酸与1,2-丙二醇反应,生成中间体癸二酸聚酯二元醇,然后将中间体与柠檬酸(CA)在一定条件下熔融缩聚制得了一种可降解弹性体聚癸二酸丙二醇柠檬酸酯(PPSC)。考察了催化剂和带水剂种类及酸醇比(摩尔比)对中间体合成工艺的影响,对中间体和PPSC进行了表征,初步研究了PPSC的物理机械性能和体外降解性能。结果表明,以对甲苯磺酸为催化剂、苯为带水剂,在酸醇比为1∶4的条件下可合成较低相对分子质量的中间体癸二酸聚酯二元醇;PPSC弹性体的玻璃化转变温度在0℃以下,于室温及人体温度下处于高弹态;PPSC为适度交联的、低模量高伸长的弹性体,其在37℃、pH值为7.4的磷酸盐缓冲溶液中具有较快的降解性(降解度超过50%)。
Intermidiate 1,2-propanediol-sebacate was synthesized with 1,2-propanediol and sebacic acid, then a novel degradable elastomer, poly[（propanediol-sebacate） -citrate]（PPSC） , was syn- thesized by melt phase polycondensation of 1,2-propanediol-sebacate and citric acid under under certain conditions. Effect of type of catalyst and water-carrying agent, mole ratio of sebacic acid to 1,2-propanediol on the synthesis of intermidiate were investigated, and the intermidiate and PPSC were characterized. The mechanical properties and in vitro degra-dation of PPSC were primarily studied. The results showed that intermidiate 1,2-propanediol-sebacate of low relative molecular mass was synthesized with toluene-p-sulfoinc acid as catalyst, benzene as water-carrying agent, and of mole ratio of sebacic acid to 1,2-propanediol of 1：4. The glass-transition temper-atures of PPSC were below 0℃ which confirmed that PPSC would be in a high-elastic state of ambient temperature and human body temperature. PPSC was a elastomer with moderate crosslinkage, low module and high elongation, and had rapid degrada- tion ratio （degradation degree more than 50%） in phosphate （pH value 7.4） at 37℃.
出处
《合成橡胶工业》
CAS
CSCD
2009年第6期471-475,共5页
China Synthetic Rubber Industry
基金
河南省基础与前沿研究立项项目(082300430330)
北京市自然科学基金重点资助项目(2061002)
