摘要
目的:研究比较甘草酸二铵及其磷脂复合物注射液在小鼠体内的组织分布,探讨甘草酸二铵磷脂复合物作为肝靶向药物的可行性。方法:将甘草酸二铵磷脂复合物溶液与甘草酸二铵水溶液分别小鼠尾静脉注射600mg.kg-1和300mg.kg-1,分别于注射后15min,30min,1h,2h,4h取血和心、肝、脾、肺、肾各组织,测定药物浓度,代入DAS2.0软件计算小鼠血浆和各组织中药物的AUC。结果:小鼠分别尾静脉注射甘草酸二铵磷脂复合物溶液与甘草酸二铵水溶液600mg.kg-1和300mg.kg-1后,体内分布结果显示:甘草酸二铵磷脂复合物静脉给药后在肝脏中的分布较甘草酸二铵水溶液中有明显提高(P<0.001),AUC为水溶液中的1.687倍。其他组织中药物的AUC基本无显著差异。结论:甘草酸二铵磷脂复合物注射液具有肝靶向性,有良好的发展前景。
Objective： To study the tissue distribution of diammonium glycyrrhizinate（DG） and its phespholipid com- plex （DGPC） injection in mice and investigate the liver targeting effect of DGPC. Methods ： The concentrations of DG in plasma, heart, liver, spleen, lung and kidney of mice were determined after intravenous administration of 300 mg·kg-1 of DG or 600 mg ·kg-1 of DGPC at 15min,30min,lh,2h,4h. The AUCs of DG in plasma or tissues were calculated by DAS 2.0 software. Results ： The tissue distribution of DGPC was different from that of free DG. In liver, the significantly higher AUC of DGPC is 1. 687 times as that of DG（P 〈0.001 ）, while the AUCs in other tissues have no significant difference. Conclusion： It is demonstrated that DGPC injection has selective targeting to liver and the liver targeted DGPC injection seems to have significant advantages and good development value.
出处
《中华中医药学刊》
CAS
2009年第11期2416-2418,共3页
Chinese Archives of Traditional Chinese Medicine
基金
杭州市科技局项目(20051333838)
关键词
甘草酸二铵
磷脂复合物注射液
体内分布
肝靶向
diammonium glyeyrrhizinate
phospholipid complex injection
tissue distribution
liver target
