摘要
目的观察血清胱氨酸蛋白酶抑制剂C(Cystatin C,简称Cys C)在新生儿高胆红素血症中的变化,评价其对肾滤过功能的影响。方法应用酶联免疫吸附法(ELISA)对68例(观察组)新生儿高胆红素血症(轻度20例,中度26例,重度22例)及无黄胆(对照组)28例新生儿血清中Cys C的水平以及血肌酐、尿素氮进行测定,并采用SPSS11.0进行统计学方差分析和t检验。结果高胆红素血症组血肌酐、尿素氮与对照组比较差异无统计学意义,而新生儿高胆红素血症时Cys C水平升高,随着胆红素的消退,Cys C水平下降。结论新生儿高胆红素时肾小球滤过功能会受损,血Cys C是评价肾小球滤过功能敏感的检测指标。
Objective To explore changes of serum cystatin C in neonate with hyperbilirubinemia,and evaluate its effect on function of glomerular filtration. Methods Serum cystatin C, blood urea nitrogen（BUN） and creatinine（Cr） of neonates in hyperbilirubinemia group and of neonates in the control group were measured by enzymelinked immunosorbent assay （ELISA）. Results There were no significant difference in serum BUN and Cr levels between the hyperbihrubinemia group and the control group. Serum Cys C levels in the hyperbilimbinemia group were significantly higher than those in the control group（ P 〈 0. 01 ）. When serum hyperbilirubinemia levels was decreased, serum Cys C levels was decreased too. Conclusion Serum Cys C can be considered as a marker of damage function of glomerular filtration of hyperbilirubinemia neonates.
出处
《中国临床新医学》
2009年第10期1025-1027,共3页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
