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TACE联合分子靶向药物治疗原发性肝癌的研究进展 被引量：8

Combination of TACE with molecularly targeted agent in management of advanced HCC
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摘要 传统放化疗对于不能手术的肝癌疗效有限,以经导管肝动脉化疗栓塞术（TACE）为主的综合治疗措施仍然是当前主要手段。然而反复的TACE可加重病人肝脏损伤,且栓塞治疗后局部缺血、缺氧,促进了血管内皮生长因子的活化,进而促进新生血管形成,导致肿瘤复发,降低疗效。近年来,分子靶向药物,尤其是多靶点索拉非尼的出现,开创了肿瘤治疗新领域,已成为当今肿瘤治疗的热点之一。TACE联合分子靶向药物具有独特优势,局部高浓度靶向药物导入及持续释放,不仅可提高抗肿瘤效果,还可弥补TACE术后复发等不足。两者具有良好的协同作用。现就TACE联合分子靶向药物治疗原发性肝癌的研究进展予以综述。
作者 王志军 王茂强
机构地区 解放军总医院介入放射科
出处 《国际医学放射学杂志》 2009年第4期374-377,共4页 International Journal of Medical Radiology
关键词 肝癌 原发性 化疗栓塞 靶向治疗
分类号 R733.7 [医药卫生—肿瘤] R735.7 [医药卫生—肿瘤]
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参考文献30

  • 1Virmani S,Rhee TK,Ryu RK,et al.Comparison of hypoxia-inducible factor-1α expression before and after transcatheter arterial embolization in rabbit VX2 la tumors[J].J Vasc Interv Radiol,2008,9:1483-1489.
  • 2Kothary N,Weintraub JL,Susman J,et al.Transarterial chem-oembolization for primary hepatocellular carcinoma in patients at high risk[J].J Vasc Interv Radiol,2007,18:1517-1526.
  • 3Sergio A,Cristofori C,Cardin R,et al.Transcatheter arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC):the role of angiogenesis and invasiveness[J].Am J Gastroenterol,2008,103:914-921.
  • 4Zhu AX.Development of sorafenib and other molecularly targeted agents in hepatocellular carcinoma[J].Cancer,2008,112:250-259.
  • 5Almhanna K,Kalmadi S,Pelley R,et al.Neoadjuvant therapy for hepatocellular carcinoma:is there an optimal approach?[J].Oncology,2007,21:1116-1122.
  • 6Pang RW,Poon RT.From molecular biology to targeted therapies for hepatocellular carcinoma:the future is now[J].Oncology,2007,72 (Suppl 1):30-44.
  • 7Thomas MB,Chadha R,Glover K,et al.Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma[J].Cancer,2007,110:1059-1067.
  • 8Liu L,Cao Y,Chen C,et al.Sorafenib blocks the RAF/MEK/ERK pathway,inhibits tumor angiogenesis,and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5[J].Cancer Res,2006,66:11851-11858.
  • 9Zhu AX.Systemic therapy of advanced hepatocellular carcinoma:how hopeful should we be?[J].Oncologist,2006,11:790-800.
  • 10Thomas MB,Abbruzzese JL.Opportunities for targeted therapies in hepatocellular carcinoma[J].J Clin Oncol,2005,23:8093-8108.

二级参考文献18

  • 1Zhong-Lin Zhang,Zhi-Su Liu,Quan Sun.Effects of thalidomide on angiogenesis and tumor growth and metastasis of human hepatocellular carcinoma in nude mice[J].World Journal of Gastroenterology,2005,11(2):216-220. 被引量：21
  • 2Llovet J, Ricci S, Mazzaferro V, et al. Randomized phase Ⅲ trial of sorafenib versus placebo in patients with advanced hepatocellular carcinoma (HCC)[J]. J Clin Oncol (Meeting Abstracts), 2007, 25: LBA1.
  • 3Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectnun oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis [J]. Cancer Res, 2004, 64(19): 7099-109.
  • 4Jordan P, Carmo-Fonseca M. Molecular mechanisms involved in cisplatin cytotoxicity[J]. Cell Mol Life Sci, 2000, 57: 1229.
  • 5Jane EP, Premkumar DR, Pollack IF. Coadministration of Sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells [J]. J Pharmacol Exp Ther, 2006, 319 (3) : 1070-80.
  • 6Liu L, Cao Y, Chen C, et al. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5 [J]. Cancer Res, 2006, 66:11851-8.
  • 7Seger R, Krebse G. The MAPK signaling cascade [J]. Faseb J, 1995, 9(9) : 726-35.
  • 8Bardwell L Mechanisms of MAPK signaling specificityIJ]. Biochem Soc Trans, 2006,34: 837.
  • 9Lee S, Yoon S, Kim DH. A high nuclear basal level of ERK2 phosphorylation contributes to the resistance of cisplatin-resistant human ovarian cancer cells [J]. Gynecol Oncol, 2007, 104(2): 338-44.
  • 10曹玮,王执民,梁志会,张洪新,王义清,关彦,李文献,潘伯荣.血管生成抑制剂TNP-470与碘化油混合栓塞肝癌的实验研究[J].世界华人消化杂志,2000,8(6):629-632. 被引量：36

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国际医学放射学杂志
2009年 第4期

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