摘要
目的比较冠状动脉内自体外周血干细胞(PBSC)移植治疗老年及非老年心肌梗死后心力衰竭患者的治疗效果与安全性。方法25例心肌梗死后心力衰竭患者,以60岁为界限分为老年组13例,非老年组12例,接受粒细胞集落刺激因子动员后的冠脉内自体PBSC移植(PBSCT)治疗。比较两组患者临床资料、冠状动脉病变及支架植入情况、PBSCT的不良反应及其前后左室形态和心功能变化。结果与非老年组比较,老年组合并高血压病、糖尿病、慢性闭塞病变,多支病变及植入支架数均较多。PBSCT6个月后,两组患者的左室舒张末期内径明显缩小,射血分数明显提高,6min步行距离明显增加,心肌灌注缺损面积均明显缩小。而两组上述参数的术前术后变化比较无显著性差异。结论冠脉内自体PBSCT治疗老年人心肌梗死后心力衰竭,能够改善患者心功能,提高生存质量,安全有效,且效果与非老年组无明显差异。
Objective To compare the efficiency and safety of intracoronary peripheral blood stem cells（PBSC） transplantation between aged patients and non-aged patients with heart failure after myocardial infarction （MI）. Methods Twenty-five patients with heart failure after MI were divided into aged group（≥60 years, n= 13） and non-aged group（〈60 years, n= 12）to receive intracoronary PBSC transplantation（PBSCT） following bone marrow cells mobilized by granulocyte colony-stimulating factor. The clinical data,coronary lesion characteristics, side effects,left ventricular shape and cardiac function between two groups were compared. Results Six months after PBSCT, the left ventricular ejection fraction and 6 min walk test distance increased significantly and left ventricular diastolic diame ter decreased obviously. The area of myocardial perfusion decreased obviously in both groups. There were no significant differences between two groups in the above parameters change. Conclusion The present study demonstrates that autologous intracoronary PBSCT is safe and feasible for elderly patients with heart failure after MI, and the left ventricular function of the patients is significantly improved. The results have no significant difference between aged group and non-aged group.
出处
《中华老年多器官疾病杂志》
2009年第5期420-424,共5页
Chinese Journal of Multiple Organ Diseases in the Elderly
基金
江苏省科技厅社会发展科技计划项目(BS2004532)
江苏省卫生厅计划项目(Z200514)
关键词
外周血干细胞移植
老年人
心肌梗死
心力衰竭
peripheral blood stem cells transplantation
elderly
myocardial infarction
heart failure
