摘要
目的:探讨急性冠脉综合征(ACS)患者住院早期(24～48h)应用不同剂量国产辛伐他汀后血清C反应蛋白(CRP)、FDP及D-二聚体影响以及血脂的变化及其临床意义.方法:连续入选ACS90例患者,随机分为3组:辛伐他汀20mg组30例、10mg组30例、对照组30例.他汀类两组均于入院24～48h内给予辛伐他汀治疗.测定三组入院时、入院后8wk高敏C反应蛋白(hs-CRP)、FDP及D-二聚体和血脂的变化.结果:ACS患者住院早期应用辛伐他汀不仅可以降低血脂水平,而且可明显降低hs-CRP,FDP及D-二聚体水平,且20mg作用优于10mg.这种益处在治疗8wk后即可见.结论:早期应用辛伐他汀可明显降低ACS患者的炎症及凝血反应,20mg作用明显优于10mg.
AIM： To evaluate the effect of early different-dose simvastatin therapy on the serum C-reactive protein （CRP）, fibrin degradation product （FDP） and D-dimer in the patients with acute coronary syndrome（ACS） , except the change of the blood-lipid. METHODS： Ninety patients with ACS were divided into 3 groups. The patients in group 1 （n = 30） received simvastatin （20 mg/d）. The patients in group 2（n =30） received simvastatin （10 rag/d） and the group 3 was the control group（n =30）. The patients in group 1 and in group 2 were treated with simvastatin within 24-48 h after hospitalization. The levels of the high sensitivity CRP （hs-CRP）, FDP, D-dimer and the blood-lipid were measured at baseline and after 8 weeks of therapy. RESULTS： After 8 weeks of therapy, early different-dose simvastatin treatmemt can not only decrease the serum level of blood-lipid, but also decrease the serum level of hs-CRP, FDP and D-dimer. The higher dose, the more effect. CONCLUSION： Early simvastatin treatmemt can inhibit inflammtion and blood coagulative reation obviously. As the dose is higher, the effect is more obvious.
出处
《第四军医大学学报》
北大核心
2009年第20期2201-2204,共4页
Journal of the Fourth Military Medical University
基金
福建省教育厅科技项目(JB08255)
关键词
辛伐他汀
急性冠脉综合征
C反应蛋白
FDP
D-二聚体
simvastatin
acute coronary syndrome
C reactiveprotein
fibrin degradation product
D-dimer
