摘要
目的:评价应变率成像定量检测肥厚型心肌病(HCM)患者左室局部与整体舒张功能的价值。方法:HCM患者33例,根据室间隔及室壁厚度分为非肥厚组(NH)、轻度肥厚组(MH)、重度肥厚组(SH);对照组31例。测量二尖瓣口血流播散速度(FPV);再获取其心尖四腔、两腔组织速度成像(TVI)图像脱机分析,测量参数:①舒张早期峰值应变(SRe);②舒张晚期峰值应变(SRa);③计算SRe/SRa。结果:与对照组比较,HCM组NH、MH、SH亚组SRe及SRs/SRe均显著降低,且NH>MH>SH;MH、SH组SRa显著降低,而NH组较对照组无显著差异,且NH>MH>SH;NH与MH组间SRe/SRa差异无统计学意义,与NH、MH组比较,SH组SRe/SRa显著减低;与对照组比较,HCM组所有室壁节段平均SRe、SRa及SRe/SRa均显著降低;HCM组所有室壁节段平均SRe及SRe/SRa与FPV呈显著正相关(分别为r=0.75和r=0.70,均为P<0.05),而SRa与FPV并无显著相关性(P>0.05)。结论:HCM患者左室局部与整体舒张功能均较正常人减低,且无论肥厚或非肥厚区域舒张功能均降低,而以肥厚节段舒张功能受损更重。
Objective： To evaluate the application of strain rate imaging（SRI） quantitatively detecting regional and global diastolic function of left ventricular（LV） in patients with hypertrophic cardiomyopathy（HCM）.Methods：Thirty-three patients with HCM and 31 controls were performed echocardiography.The HCM patients were divided into three groups by the thickness of interventriclar septum and left ventricular posterior wall as： non-hypertrophy（NH）,mild hypertrophy（MH）,and severe hypertrophy（SH） groups.Flow propagation velocity（FPV） were measured.Tissue velocity imaging（TVI） of all the patients and controls were performed in apical four-and two-chamber views.The indices included： peak strain rate in early diastole（SRe）,peak strain rate in late diastole（SRa） and SRe/SRa.Results：Compared those in controls,SRe and SRe/SRa of the three HCM groups decreased significantly（NH〉MH〉SH）;SRa in MH and SH groups decreased significantly,but no statistical changes in SRa were found between NH group and c...更多ontrols,and NH〉MH〉SH.Compared with that in NH and MH groups,SRe/SRa in SH group decreased significantly,but there was no significant difference of SRe/SRa between NH and MH groups.Mean SRe and SRe/SRa of all segments in patients with HCM were lower than those in controls significantly,and each was significantly correlated with FPV respectively（r=0.75 and r=0.70,respectively,and both P〈0.05）;but there was no correlation between SRa and FPV.Conclusion： The regional and global diastolic function of LV in patients with or without hypertrophy was damaged,and can be evaluated quantitatively and accurately by SRI.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2009年第5期676-679,I0004,共5页
Medical Journal of Wuhan University
关键词
应变率成像
肥厚型心肌病
左室
舒张功能
Strain Rate Imaging
Hypertrophic Cardiomyopathy
Left Ventricular
Diastolic Function
