摘要
原发性恶性胃淋巴瘤(primary malignant gastric lymphoma,PMGL)是仅次于胃癌的高发胃肿瘤,胃原发性淋巴瘤的病因及发病机制尚不明了。PMGL发病初期常无症状,随着疾病的发展,逐渐出现一些非特异性的消化道症状和体征,与消化道的良性疾病或消化道癌的表现难以区别。PMGL的分类可参照WHO的B细胞及T细胞淋巴瘤的分类标准。由于胃恶性淋巴瘤临床表现缺乏特异性,因此其术前诊断率不高。胃镜检查是术前诊断的主要手段,镜下常表现为胃腔内巨大隆起性黏膜下肿块或表浅的溃疡,与良性淋巴细胞增生和分化差的胃癌较难鉴别。随着影像学技术的发展,国外报道EUS作为评价胃淋巴瘤浸润范围、组织类型及对治疗的反应有重要价值。目前,对于胃原发性淋巴瘤尚无统一和公认的最佳治疗方案,但其总体趋势是向综合治疗发展,尽量进行胃保留的手术治疗,以提高患者生存质量为治疗目的。
Primary malignant gastric lymphoma （PMGL） ranks the second in morbitidy of gastric tumors,next to gastric caner. Etiology and pathogenesis of PMGL are still not fully understood. There is no symptomat the initial phase of PMGL. Nonspecific symptom and syndrome appears gradually with the growing ofPMGL. So it is difficult to differentiate the clinical features of PMGL from those of benign tumors or cancers ofgastrointestinal tract. Classification of PMGL refers to classifying criteria for B cell lymphoma and T cell lymphomadescribed by WHO. Lack of specific clinical characteristics or features of PMGL results in low preoperativediagnostic rate. Endoscopy is a major method to diagnose PMGL preoperatively. With the developmentof imaging diagnosis, edoscopic ultrasonography （EUS） plays an important role in evaluating the invasive extent,histologic type and response to treatment of PMGL. At present, although there is not an ideal and generallyaccepted therapy for PMGL, comprehensive treatment will be a trend with the goal of improving patients’quality of life with the preservation of the stomach.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2009年第19期1137-1140,共4页
Chinese Journal of Clinical Oncology
关键词
淋巴瘤
胃肿瘤
胃镜检查
胃淋巴瘤
Lymphoma
Gastric tumor
Endoscopy
Gastric lymphoma
