摘要
肥大细胞(mast cell,MC)是过敏性疾病的关键细胞之一。机体的过敏反应很大程度依赖于肥大细胞膜上的特异性受体FcεRI。肥大细胞膜上交联的FcεRI引发了下游的一系列信号事件并导致脱颗粒,包括细胞因子及趋化因子产生以及白三烯的释放。由于IgE在过敏反应中的重要作用,现在的研究主要集中在FcεRI下游的信号事件。其脱颗粒的分子机制是一个由多种蛋白质分子介导的,各个环节受到精确调控的复杂过程。对肥大细胞脱颗粒分子机制的深入研究将给过敏性疾病提供一个新的治疗方案。
Mast cells are central cells of allergic diseases. Their involvement in allergic reactions is largely dependent on activation of the specific receptor for IgE （FceRI）. Cross-linking of FceR1 on mast cells initiates a cascade of signaling events that eventually results in degranulation, cytokine/chemokine production, and leukotriene release, contributing to allergic symptomology. Because of the importance of IgE in allergy, much focus has been placed on deciphering the signaling events that take place downstream of FceR1. Understanding the molecular mechanisms underlying mast cell activation ideally will provide insights into the development of novel therapeutics to control allergic disease.
出处
《现代生物医学进展》
CAS
2009年第18期3539-3541,3535,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金(30700344
30873077)
上海市基础研究重点项目(08JC1404900)
上海市卫生局青年科研项目(2006Y040)资助项目
