摘要
目的：探讨大黄对多器官衰竭大鼠肠粘膜屏障的保护作用。方法：６０只大鼠随机分为对照组、生理盐水治疗组和大黄治疗组，以酵母多糖Ａ制作多器官衰竭模型，观察肠道细菌移位、血浆内毒素水平、肠粘膜的病理变化。结果：大黄治疗组血及内脏中细菌移居数量减少，血浆内毒素水平低，小肠病理损害轻，并有杯状细胞增生。结论：大黄对多器官衰竭大鼠肠粘膜屏障有保护作用。
Objective:To determine effect of rhubarb on barrier of intestinal mucosa in rats with MOF.Methods:60 Sprague Deawley rats were divided into 3 groups,MOF treated with rhubarb(RH) group,MOF treated with normal saline(NS) group,and control group.Results:The results show that the rats treated with rhubarb exhibited a very lower degree of endotoxemia than did the rats in NS group.The incidence of bacterial translocation and number of viable bacteria contained in the blood,liver mesocolon of the rats in the RH group were much lower than that in the NS group ( P <0.01),microscopic examination showed the degree of histologic damage in the jejunum of the rats in RH group was less than that in the NS group.Conclusions:All the results suggested that rhubarb had an obvious curative effect on barrier of intestinal mucosa in rats with MOF.
出处
《蚌埠医学院学报》
CAS
1998年第6期380-381,共2页
Journal of Bengbu Medical College
关键词
多器官衰竭
大黄
肠粘膜
保护
multiple organ failure
rhubarb
intestinal mucosa
