摘要
ＭＡＲ（ｍａｔｒｉｘａｓｓｏｃｉａｔｉｏｎｒｅｇｉｏｎｓ）是真核基因组的ＤＮＡ序列中可特异性地与核基质紧密结合的区域．ＭＡＲ通过特异性地与一些ＭＡＲ结合蛋白相互作用，在真核基因的复制和表达调控以及染色体的包装构建等方面发挥重要作用．ＭＡＲ结合蛋白主要包括一些构成染色质或核基质的结构蛋白（如组蛋白Ｈ１、拓扑异构酶Ⅰ和Ⅱ、ＨＭＧＩ／Ｙ、ＬａｍｉｎＢ１、Ｍａｔｒｉｎ等）以及一些组织特异性表达的蛋白（如ＳＡＴＢ１、骨钙蛋白基因启动子结合因子等）．根据它们与核基质的关系将ＭＡＲ结合蛋白分为三类：核基质富含组分、核基质稀有组分以及非核基质组分，对其与ＭＡＲ的相互作用进行了比较和分析．
Matrix association region (MAR) is the DNA sequences in eukaryotic genome which can specifically associate with the nuclear-matrix. By means of specific interaction with some MARbinding proteins, MAR plays important roles in eukaryotic gene's replication, expression and regulation, and chromosomal construction. MARbinding proteins include some structural proteins in chromatin or nuclear matrix (such as histone H1, topoisomerase Ⅰ & Ⅱ, HMG I/Y, lamin B1, and matrins.) and some tissuespecifically expressed proteins, including SATB1 (special ATrich binding protein 1) and osteocalcin gene promoterbinding factors. By the relationship with the nuclear matrix, these MARbinding proteins can be classified in three groups, nuclear matrixabundant composition, rare composition and nonnuclear matrix composition. Their interactions with MARs were compared and analyzed as well.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1998年第4期307-310,共4页
Progress In Biochemistry and Biophysics
关键词
MAR
核基质
MAR结合蛋白
matrix association region (MAR), nuclear matrix, MARbinding proteins
