摘要
论述了如何改进腺病毒载体以提高其有效性和安全性．腺病毒载体是将基因转移到体内多种不同细胞的有效运载工具．第一代腺病毒载体已证明在基因治疗中有很好的前途，虽然它在有效性和安全性方面还存在不足之处，但这些局限正在被逐步克服．
Adenoviruses are efficient gene transfer vectors for variety of cell types in vivo. The firstgeneration recombinant adenoviruses that lack E1 sequences have shown tremendous promise in animal and human models of gene therapy. Having some limitations at aspect of efficacy and safety,the adenovirus vectors are being gradually improved to resolve these problems. The developments of construction of adenovirus vectors in increasing the efficacy and safety was described.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1998年第4期304-307,共4页
Progress In Biochemistry and Biophysics
基金
卫生部基金
