摘要
目的研究子宫颈癌中C-erbB-2基因的表达,探讨C-erbB-2在宫颈癌发生发展中的作用,及作为一种肿瘤标记物用于临床筛查判断和判断预后的临床意义。方法应用免疫组织化学的方法检测C-erbB-2基因在宫颈癌32例,慢性宫颈炎20例(对照组)的表达。用卡方检验(Chi-Square Test)检测C-erbB-2在实验组和对照组中的表达是否有差异。结果C-erbB-2在慢性宫颈炎、宫颈癌组织中的阳性表达率分别为68.75%、30%,两者间具有统计学意义(P<0.05),C-erbB-2的表达与宫颈癌的临床分期呈正相关(P0.01)。结论C-erbB-2作为影响细胞凋亡因子,在宫颈癌的发生、发展过程中起一定作用。
Objective： Study the expressions of C -erbB -2 gene in cervix cancer, probe into them and play a developing role at the cervical carcinoma, and is used in sifting and checking the clinical meaning that judges and judging the prognosis clinically as a kind of tumour mark thing. Methods ： Use the immunity to organize the chemistry method to measure C - erbB - 2 gene at 32 cases of cervical carcinoma, the expressions of chronic 20 of palace neck inflammation （ contrast the group ）. Whether examine （ Chi - Square Test ） and have a difference to examine C - erbB - 2 in the experiment group and contrast the expression in the group with the card side. Results ： The positive expression rate in chronic palace neck inflammation , cervical carcinoma are organized of C - erbB - 2 is 68. 75% , 30% respectively, having a statistics meaning （ P 〈0. 05 ） between the two, the expression of C - erbB -2 and clinic of the cervical carcinoma present positive correlation （ P 〈0. 01 ） by stages. Conclusion： The factor that C -erbB -2 withers to die as influencing cells, C - erbB - 2 plays a certain role in the course of emergence , developing of the cervical carcinoma
出处
《中国优生与遗传杂志》
2009年第10期29-30,9,共3页
Chinese Journal of Birth Health & Heredity
基金
湖南省教育厅科学研究项目(编号:07C059)
