摘要
目的:评价社区美沙酮维持治疗的安全性。方法:对广东省首批美沙酮维持治疗门诊的445例患者在入组1、3、6月和1a后随访其不良反应和戒断症状,从门诊获得美沙酮管理资料。结果:133例报告有不良反应,以消化系统症状为主,不良反应的种类和发生人次数随治疗时间延长减少。最常见的戒断症状是"吃饭没胃口"和"晚上睡觉很容易醒"。尚未发生美沙酮非法流失事件。结论:广东省首批社区美沙酮维持治疗的安全性较好。
Objective： To evaluate the safety of community - based methadone maintenance treatment. Methods：A follow -up study was conducted at 1 - ,3 - ,6 -, 12 months after treatment among 445 patients recruited in the first approved community -based methadone maintenance treatment clinics in Guangdong Province for adverse drug reaction and withdrawal symptoms. Methadone management information was achieved from clinics. Results：One hundred and thirty three patients reported adverse drug reactions. The main adverse reaction was symptoms of digestive system. Types and incidence of adverse reactions were gradually reduced over the treatment time. The most common withdrawal symptoms were ＇ no appetite＇ and ＇ wake up easily＇. No drugs illegally flowed into the market causing social harm. Conclusion： No serious adverse reactions and withdrawal symptoms occurred during methadone maintenance treatment. Incidence of adverse reaction and withdrawal symptoms can reduce over treatment time. No safety problem was found in methadone management.
出处
《中国药物依赖性杂志》
CAS
CSCD
2009年第5期420-423,445,共5页
Chinese Journal of Drug Dependence
基金
2003年广东省艾滋病防治项目基金(2003101)
关键词
美沙酮维持治疗
安全性评价
不良反应
戒断症状
社会安全性
methadone maintenance treatment
safety evaluation
adverse reactions
withdrawal symptoms
social safety
