摘要
Immune cells that undergo increased apoptosis include lymphocytes and macrophages,yet the apoptosis of neutrophils is decreased in sepsis.Increase in apoptosis has also been reported in non-immune cells such as gastrointestinal cells,epithelial cells of lung as well as endothelial cells.The altered apoptotic cell death may contribute to the initiation and aggravation of immune and organ dysfunction in sepsis.Elucidating the changes and mechanism of apoptosis and taking measures to control apoptosis may be an effective strategy for the treatment of sepsis.
Immune cells that undergo increased apoptosis include lymphocytes and macrophages, yet the apoptosis of neutrophils is decreased in sepsis. Increase in apoptosis has also been reported in non - immune cells such as gastrointestinal cells, epithelial cells of lung as well as endothelial cells. The altered apoptotic cell death may contribute to the initiation and aggravation of immune and organ dysfunction in sepsis. Elucidating the changes and mechanism of apoptosis and taking measures to control apoptosis may be an effective strategy for the treatment of sepsis.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2009年第10期2068-2072,共5页
Chinese Journal of Pathophysiology
基金
国家863计划资助项目(No.2006AA02Z176)
国家自然科学基金资助项目(No.30370071
No.30670102)
