摘要
目的检测RIP,Caspase-8在口腔鳞癌及癌前病变中的表达情况,探讨其在口腔鳞癌及癌前病变中的作用及意义。方法采用SABC法免疫组化方法检测22例口腔鳞癌﹑14例口腔扁平苔藓﹑14例口腔白斑﹑10例正常口腔黏膜中RIP和Caspase-8表达的情况。结果RIP在正常口腔黏膜中以阴性和弱阳性表达,各占50%(5/10),而在口腔扁平苔藓、口腔白斑、口腔鳞癌主要以弱阳性和阳性表达,占75%(36/50),且在口腔鳞癌中的表达明显高于其他组,以阳性和强阳性表达为主,占63.7%(14/22)(P<0.05);Caspase-8在各组均以弱阳性、阳性、强阳性表达为主,其阳性表达率正常口腔黏膜80%(8/10),口腔扁平苔藓100%(14/14),口腔白斑85.7%(12/14),口腔鳞癌100%(22/22)。结论RIP,Caspase-8在口腔鳞癌及癌前病变的发生和发展中均起一定的作用。
Objective To detect the expressions of receptor-interacting protein （RIP） and caspase-8 and investigate their roles in oral squamous cell carcinoma （OSCC） and oral precancerous lesions. Methods SABC immunohistochemical methods were used to detect the expressions of RIP and caspase-8 in 22 specimens of OSCC, 14 specimens of oral lichen planus （OLP）, 14 specimens of oral leukoplakia （OLK） and 10 specimens of normal oral mueosa （NOM）. Results The rate of weak or negative expression of RIP in normal mucosa was 50% （5/10）. The rates of weak and positive expression of RIP in OLP, OLK and OSCC were 75% （36/50）, and the rate of positive and strong expression of RIP was 63.7% （14/22） in OSCC, significantly higher that in the others groups （P〈0.05）. The rates of weak, positive and strong positive expression ofcaspase-8 in NOM, OLP, OLK and OSCC were 80% （8/10）, 100% （14/14）, 85.7% （12/14）, and 100% （22/22）, respectively. Conclusion Both RIP and caspase-8 may play important roles in the occurrence and progression of OSCC and oral precancerous lesions.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2009年第9期1802-1805,共4页
Journal of Southern Medical University
基金
广东省医学科研基金项目(A2006338)
