摘要
目的回顾胃肠转流手术治疗2型糖尿病的临床实践及治疗机理的研究,为深入认识2型糖尿病的发病机理和制定综合治疗策略提供基础。方法综述既往临床胃肠转流手术治疗2型糖尿病的文献和循证分析,以及当前对其作用机理的认识和理论研究的进展。结果2型糖尿病发病率增长迅速,药物治疗效果欠佳。临床实践证实,胃肠转流手术治疗2型糖尿病能获得确切疗效,关于其作用机理主要有3个理论假说:远端肠道作用机理假说、近端肠道作用机理假说和肠降糖素平衡假说。结论胃肠转流手术治疗2型糖尿病可获得良好疗效,但仍然缺乏深入的基础实验研究阐明其作用机理。
Objective To study the mechanism of gastric bypass operation on treatment of type 2 diabetes mellitus,recognize the etiology and pathogenesy of the disease and frame therapy strategy for type 2 diabetes mellitus.Methods The literatures about gastric bypass operation on treatment of type 2 diabetes mellitus,including clinical cases reports and evidence-based studies were reviewed.Results Gastrointestinal bypass operation was regarded as an effective treatment for type 2 diabetes mellitus.There were three hypotheses of therapy mechanism： early delivery of nutrients to the distal intestine,exclusion of the proximal intestine and incretin/anti-incretin.Conclusion Gastrointestinal bypass operation is now considering as an effective treatment,there is still a lack of basic experimental studies to clarify the mechanism.
出处
《中国普外基础与临床杂志》
CAS
2009年第10期866-868,共3页
Chinese Journal of Bases and Clinics In General Surgery
关键词
2型糖尿病
胃肠转流手术
Type 2 diabetes mellitus
Gastric bypass operation
