摘要
牙周膜干细胞(PDLSCs)是维持牙周组织动态平衡和缺损修复的关键细胞,也是牙周组织再生治疗新策略的基础。近年来研究证明PDLSCs具有良好的增殖和分化能力,然而在不同因素的影响下其功能也呈现出较大的差异性。研究这些影响因素不仅有助于深入认识和发掘PDLSCs的生物学功能,而且对今后基于干细胞的牙周疾病治疗具有理论指导意义。该文就影响PDLSCs功能的多种重要因素作一叙述,并展望其在牙周缺损再生修复治疗中的应用前景。
Periodontal ligament stem cells（PDLSCs） are not only the crucial type of cells in maintaining dynamic homeostasis and wound repair of periodontal tissues but also the basis for novel therapeutic strategy for periodontal regeneration.Although possessing the excellent proliferation and differentiation ability,PDLSCs behave differently under various conditions representative of several influential factors.Understanding of these influential factors will help us to exploit more about PDLSCs,and more importantly,lead a new modality in treating periodontal diseases based on stem cells.Here we review multiple important factors affecting function of PDLSCs and propose its use in future regenerative therapy of periodontal defects.
出处
《实用口腔医学杂志》
CAS
CSCD
北大核心
2009年第5期737-740,共4页
Journal of Practical Stomatology
关键词
牙周
牙周膜干细胞
微环境
细胞分化
Periodontium
Periodontal ligament stem cells
Microenvironment
Cell differentiation
