摘要
目的:探讨降脂护肝胶囊对非酒精性脂肪性肝病(NAFLD)的疗效。方法:采用高胆固醇高脂饮食喂养,复制NAFLD大鼠模型,设降脂护肝胶囊治疗组(Z组)、模型组(M组)及空白对照组(K组),检测各组大鼠血清ALT、AST、TG、TC、TNF-α、IFN-γ水平及肝组织SOD活性、MDA浓度,观察肝脏组织病理学变化。结果:M组大鼠ALT、AST、TG、TC、MDA、TNF-α、IFN-γ水平明显升高,而SOD表达下降,与K组比较,差异有显著性意义(P<0.01或P<0.05);Z组大鼠的8次指标检测结果均得到明显改善,与M组比较,差异有显著性意义(P<0.01或P<0.05)。M组大鼠肝脏脂肪变明显,且有散在坏死灶及炎性细胞浸润;Z组大鼠肝脏脂肪变比M组明显减轻,肝窦基本正常,无炎性细胞浸润。结论:降脂护肝胶囊能显著改善非酒精性脂肪肝大鼠的肝功能,降低血脂,提高肝细胞SOD活性,降低MDA含量,抑制炎症反应中细胞因子TNF-α、IFN-γ,改善肝组织学病理情况,对非酒精性脂肪性肝病有较好的治疗效果。
Objective： To investigate the efficacy of Jiangzhi Hugang capsule （JZHGJN） in the treatment of rat nonalco- holic steatohepatitis （NASH） . Methods： Duplicate the animal steatohepatitis model with fat-rich and chol-rich diet. Sixty SD male rats were randomly divided into 3 groups including the therapy group, the model group and the mormal control group. Blood sample were collected for the detection of serum ALT, AST, TG, TC and liver tissues were obtained for the detection of SOD, MDA including TNF-α and IFN-γlevels. The pathological changes were observed under light microscope. Results ： In comparison with those of normal rats, the contents of SOD were decreased significantly in the model rats but ALT, AST, TG, TC, MDA were increased significantly in the model group （ P 〈 0.01 ） . The above-mentioned markers were obviously improved in the med- ication rats （P 〈 0. 01 ）, and the degree of fatty degeneration was also alleviated. Conclusion ： JZHGJN has definite effect on repairing the damage of hepatocyte and decreased the lever of the serum TG, TC ; It can also increase the activity of SOD and re- duce the content of MDA and prevent the activity of cytokine such as TNF-α IFN-γ during inflammatory reaction and amend pathological damage in hepatic tissues. JZHGJN has significantly therapeutic effect on nonalcoholic steatohepatitis rats.
出处
《中西医结合肝病杂志》
CAS
2009年第5期304-305,313,321,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
