摘要
应用免疫组织化学ABC法对20例膀胱腺癌和16例腺性膀胱炎的膀胱组织进行了P53和P21基因蛋白表达产物的检测。结果20例膀胱腺癌中，P53基因蛋白表达10例，占50．0％；P21基因蛋白表达18例，占90．0％。16例腺性膀胱炎中，P21基因蛋白表达6例，占37．5％；P53基因蛋白表达2例，占12．5％，且均有结构不良及非典型增生。表明膀胱腺癌P53和P21基因蛋白表达率比腺性膀胱炎多，经统计学检验有极显著性差异（P＜0．01）。认为腺性膀胱炎一般只在结构不良与非典型增生时可见。
The protein expressions of P53 and P21 from 20 bladder adenocarcinomas and 16cystitis glandularis were tested by immunohistochemistry (ABC). The results showed that 12 samples (60.0% ) expressed the P53 protein and 18 samples (90.0% ) expressed the P21 protein in 20bladder adenocarcinoma samples,but 6 samples (37. 5% ) expressed the P21 protein and 2 samples(12. 5% ) expressed the P53 protein in 16 cystitis glandulars with atypical hyperplasia dysplasia, P＜0.01. The expressions of P53 and P21 in bladder adenocarcinoma were higher than that in cystitisglandulatis.
出处
《临床泌尿外科杂志》
1998年第11期503-505,共3页
Journal of Clinical Urology
