摘要
目的探讨血管活性物质与细胞膜离子转运的关系及其在高血压病（ＥＨ）发病中的作用。方法观察１０７例ＥＨ患者和３０例正常人血浆多种血管活性物质、淋巴细胞离子泵和阳离子变化，并对血压与１３个相关预选因子进行逐步回归分析。结果ＥＨ患者血浆内皮素、血管紧张素Ⅱ、内源性洋地黄物质、去甲肾上腺素和心钠素增高，它们彼此相关并与淋巴细胞钠泵和钙泵活性下降、Ｎａ＋和Ｃａ２＋浓度升高相关，其中血管紧张素Ⅱ、去甲肾上腺素、心钠素、细胞钠泵和Ｎａ＋与血压之间有独立的相关关系。结论体循环中多种血管活性物质含量改变和相互作用与细胞膜离子转运缺陷有密切的内在关系，并可能在ＥＨ的发病过程中起协同和促进作用。
Objective To sutdy the effect of vasoactive substances and cell cation transport function in the pathogenesis of essential hypertension (EH). Methods Plasma endothelin (ET), angiotensin Ⅱ (AngⅡ), endogenous digitalis like substances (EDLS), norepinephrine (NE) and atrial natriuretic peptide (ANP) were determined, lymphocytic membraneion pumps and cations were also measured in 107 EH patients and 30 healthy subjects. Multiple stepewise regression analysis was computed using blood pressure as dependent variable and 13 parameters as independent variables. Results It was found that in EH patients, ET, AngⅡ, EDLS, NE and ANP were all increased and correlated with each other. The increase of ET, AngⅡ, EDLS, NE and ANP were closely related to the decrease of Na + K + ATPase and Ca 2+ ATPase activities and the enhance of Na + and Ca 2+ . The regression equation revealed that AngⅡ, NE, ANP, Na + K + ATPase activity and Na + were the independent factors affecting blood pressure in EH patients. Conclusion The changes of vasoactive substances levels in the circulation and cation transport function in the cell, or the interaction among them may play important roles in the pathogenic mechanisms of EH.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
1998年第5期340-342,共3页
Chinese Journal of Cardiology
基金
贵州省教委科研项目资助
