摘要
目的：探讨盐酸苯那普利对冠心病心力衰竭患者校正后ＱＴ间期离散度（ＱＴｃｄ）的影响及发生机制。方法：采用随机双盲法对４０例冠心病心力衰竭患者（ＮＹＨＡⅡ～Ⅲ级）口服盐酸苯那普利（治疗组２０例）和安慰剂（安慰剂组２０例）治疗６周，并对治疗前后的ＱＴｃｄ、左心室射血分数（ＬＶＥＦ）、血管紧张素Ⅱ及醛固酮进行检测及分析。并设正常组２０例作对照。结果：经盐酸苯那普利治疗后，ＬＶＥＦ明显提高，ＱＴｃｄ、血管紧张素Ⅱ、醛固酮明显降低；ＬＶＥＦ和血管紧张素Ⅱ呈一定负相关（ｒ＝－０．２９９，Ｐ＜０．０５），但不呈线性关系；ＬＶＥＦ和醛固酮呈负相关，但相关性更弱（ｒ＝－０．１４５，Ｐ＞０．０５），且ＬＶＥＦ也和ＱＴｃｄ呈一定负相关（ｒ＝－０．２９８，Ｐ＜０．０５）。结论：盐酸苯那普利治疗冠心病心力衰竭除与其能阻滞肾素—血管紧张素—醛固酮系统有关外。
Objective:To explore the effects of benazepril hydrochloride on corrected QT dispersion (QTcd) in patients with congestive heart failure (CHF:NYHAⅡ～Ⅲ)secondary to coronary heart disease(CHD)and mechanism. Methods:Forty patients with CHF secondary to CHD were double blindly randomized into treatment group 20 and placebo group 20.QTcd,angiotensin Ⅱ(Ang Ⅱ),aldosteron (Ald) and left ventricular ejection fraction(LVEF) were measured,and normal group 20 as controls. Results:LVEF was increased significantly and QTcd,AngⅡ and Ald were lowered significantly in Benazepril treated group after 6 weeks.No consistent changes were observed in the placebo group.AngⅡ and QTcd showed negative relationship with LVEF( r =-0.299, p <0.05; r =-0.298, p <0.05,respectively)without linear relation.Ald showed mild negative relationship with LVEF( r =-0 145, p >0.05). Conclusion:Benazepril hydrochloride can improve heart function of CHF secondary to CHD.Benazepril hydrochloride can not only inhibite renin angiotensin aldosteron system but also reduce QTcd.
出处
《中国循环杂志》
CSCD
北大核心
1998年第5期277-279,共3页
Chinese Circulation Journal
关键词
苯那普利
冠心病
心力衰竭
QTCD
药物疗法
Benazepril hydrochloride
Coronary heart disease
Congestive heart disease
Corrected QT dispersion
