摘要
目的：冠状动脉造影（ＣＡＧ）评价静脉溶栓治疗急性心肌梗死（ＡＭＩ）的疗效及安全性。方法：１１０例ＡＭＩ患者应用国产尿激酶及进口链激酶开始溶栓治疗后９０分钟行ＣＡＧ。结果：尿激酶和链激酶血管开通率分别为６０．８％及６３．０％；ＣＡＧ提示有残留血栓的分别为８６．９％及８１．５％；５周病死率分别为８．６％及７．４％；严重出血并发症分别为１．８５％及２．１７％，均无统计学意义。加大尿激酶剂量至２００ＩＵ，并不增加血管开通率反而增加出血并发症。结论：ＡＭＩ是由突然冠状动脉血栓性闭塞所致。尿激酶和链激酶用于静脉溶栓治疗可使闭塞的冠状动脉再通。
Objective:The therapeutic effect and safety of intravenousthrombolysis on acute myocardial infarction (AMI) was evaluated by coronaryangiography (CAG). Methods:One hundred and ten patients with AMI were receivedurokinase(UK) or streptokinase(SK) for thrombolysis.Ninety minutes after that CAG was performed. Results:In group UK and SK,the reopening rate of infarct relatedartery(IRA)was 60.8% and 63.0%,the remained thrombus was 86.9% and 81.5%,the 5 week case fatality rate was 8.6% and 7.4%,and theintracranial hemorrhage was 1.85% and 2.17%.As the dosage of UK was increased up,the rate of reperfusion did notchange,but the increased bleeding tendency. Conclusion:AMI is caused by sudden coronary occlusion of thrombus.The results suggest that UK and SK are similar in safety andtherpeutic effect in the therapy of AMI.
出处
《中国循环杂志》
CSCD
北大核心
1998年第5期268-270,共3页
Chinese Circulation Journal
关键词
心肌梗死
冠状动脉
AMI
溶栓疗法
Acute myocardial infarction
Thrombolysis
Coronaryangiography
