摘要
目的探讨小剂量螺内酯联合卡维地洛治疗慢性心力衰竭(CHF)患者的临床疗效。方法将136例CHF患者随机分为两组,每组68例,两组均使用常规治疗,观察组再加用小剂量螺内酯和卡维地洛治疗,随访10个月,评估心功能分级变化,超声心动图测量左室舒张末期内径(LVDD),左室收缩末期内径(LVSD),左室射血分数(LVEF),每搏输出量(SV),心脏指数(CI)。结果(1)两组治疗后均有效,观察组心功能改善显著,总有效率明显优于对照组(92.5% VS 73.5%,P<0.05),(2)观察组超声心动图测量的各项指标变化显著。结论CHF患者长期使用小剂量螺内酯和卡维地洛有益于改善心功能,提高生活质量。
Objective To study the clinical efficacy of low - dose spironolactone combined with carvedilol in patients with chronic heart failure （CHF）. Methods One hundred and thirty six CHF patients were randomly divided into two groups of 68 each and both groups received conventional treatment. The observation group was administered additionally low - dose spironolactone and carvedilol. The changes in cardiac function grades were assessed by echocardiography to measure left ventricular end diastolic diameter （LVDD）, left ventricular end systolic diameter （LVSD）, left ventricular ejection fraction （LVEF）, stroke volume （SV）, and cardiac index （CI）. Results The treatment was effective in the two groups. Cardiac function was significantly improved in the observation group,the total effective rate was higher than that in the control group （92.5% vs 73.5%, P 〈0.05）. Indicators measured by echo- cardiography were changed significantly in the observation Group. Conclusions Longterm low- dose spironolactone and carvedilol therapy improves cardiac function and quality of life in CHF patients.
出处
《武警医学》
CAS
2009年第10期917-919,共3页
Medical Journal of the Chinese People's Armed Police Force
关键词
螺内酯
卡维地洛
慢性心力衰竭
Spironolactone Carvedilol Chronic heart failure
