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缬沙坦联合苦参素治疗慢性乙型病毒性肝炎肝纤维化效果观察 被引量:4

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摘要 目的:观察缬沙坦联合苦参素治疗慢性乙型病毒性肝炎(乙肝)肝纤维化的效果。方法:将58例慢性乙肝随机分为治疗组和对照组,每组各29例。两组均予常规抗病毒、护肝治疗及苦参素0.2 g每日3次口服;治疗组在上述治疗基础上加用缬沙坦80 mg,每日1次口服。于治疗前及治疗6个月时采用酶链免疫法检测血清透明质酸、Ⅲ型前胶原肽、Ⅳ型胶原及层粘连蛋白等肝纤维化指标。结果:两组治疗6个月时血清肝纤维化指标均较治疗前下降,差异有统计学意义(P<0.05,P<0.01);治疗6个月时治疗组各肝纤维化指标均较对照组明显下降,差异有统计学意义(P<0.05,P<0.01)。结论:缬沙坦能有效降低血清肝纤维化指标水平,具有一定的抗肝纤维化作用,联合苦参素治疗效果更佳。
机构地区 解放军
出处 《临床误诊误治》 2009年第10期76-77,共2页 Clinical Misdiagnosis & Mistherapy
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