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少突胶质细胞发育分化的转录调控 被引量：2

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摘要 少突胶质细胞(OL)的成熟分化是中枢神经髓鞘形成的关键环节。在少突胶质细胞形成、增殖、分化、成熟的发育过程中,骨形态发生蛋白(BMP)、sonic hedgehog(Shh)、Notch等三种信号通路发挥了重要的调控作用。这些通路最终激活或抑制下游一系列特异性转录因子(TFs)而完成对OL谱系特异性标志基因表达的激活。各种TFs在特定条件下的时空表达和相互作用是OL发生、发育、分化的重要调控方式。
作者 王晗知 蔡文琴 肖岚
机构地区 第三军医大学基础部组织学与胚胎学教研室
出处 《生理科学进展》 CAS CSCD 北大核心 2009年第4期353-356,共4页 Progress in Physiological Sciences
基金 国家自然科学基金(30672447) 重庆市科委归国基金(2007)资助课题
关键词 少突胶质细胞 发育 分化 转录因子
分类号 R329.2 [医药卫生—人体解剖和组织胚胎学]
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参考文献9

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同被引文献36

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生理科学进展
2009年 第4期

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